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5 days ago · SARS-CoV-2 undergoes mutations (including substitutions, deletions, and insertions) in viral proteins to enhance its fitness and exhibit different characteristics . The spike (S) protein is critical for attachment to receptors, mainly angiotensin-converting enzyme 2 (ACE2), triggering virus entry into target cells .
1 day ago · The common raccoon dog (Nyctereutes procyonoides) was the most genetically abundant animal in the samples, they report, but genetic material from the masked palm civet (Paguma larvata) also turned up in a stall with RNA from SARS-CoV-2. Both species were linked with the original SARS outbreak, the researchers note, and common raccoon dogs have ...
3 days ago · Complete inhibition of SARS-CoV-2-nsp5 T169I nsp12 V792I virus replication was observed with a dose of 6.26 µM of nirmatrelvir (2-fold higher than for WT virus) in pre- and post-treatment ...
1 day ago · The SARS-CoV-2 virus, which causes COVID, is continuing to mutate, giving rise to new, highly contagious variants. The latest one to gain interest and make headlines is the recombinant variant ...
3 days ago · Researchers isolated SARS-CoV-2 strains, which are drug resistant with mutations to the nsp12 protein that is the target of remdesivir and another variant with mutations to the nsp5 protein, the target of Paxlovid. These mutations help the virus persist in people with compromised immunity despite common antiviral treatments. Credit: Shutterstock
3 days ago · Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections. Nature Communications , 2024; 15 (1) DOI: 10.1038 ...
3 days ago · The researchers went straight to the source—human blood samples—to find antibodies that target regions of the S2 subunit of the spike protein. These samples came from two individuals who recently recovered from SARS-CoV-2 infection. Monoclonal antibodies were generated based on sequences from isolated spike-specific memory B-cells.
