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Jan 18, 2008 · European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry.
- Chao Tian, Robert M Plenge, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Se...
- 2008
Jan 15, 2024 · Eurospace. Eurospace is the trade association of the European Space Industry. It is a non-profit European organisation created in 1961. Eurospace member companies today represent 90% of the total turnover of the European Space Industry. Eurospace fosters the development of space activities in Europe and promotes a better understanding of space ...
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Do European population substructures correspond to geographic relationships?
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- Population Differentiation Among European Populations
- Principal Components Analyses Using >250,000 SNPs
- PCA of Northern and Southern European Population Groups
- PCA of European and South Asian Population Groups
- Identification and Testing of European Substructure Ancestry Informative Markers
- Performance of Esaims in Controlling For Population Substructure
To examine similarities and differences in population differentiation among European and closely related populations, paired Fst values were determined between 18 population groups that were typed with genome-wide SNP arrays (see Materials and Methods). The studies included genotypes derived from HGDP (14), and samples collected in Europe and Europ...
To further explore the relationship among European population groups and examine population substructure, PCA was performed using the genotype results from a set of ~300,000 autosomal SNPs that was common to each of the populations examined. For most individuals with self-reported ethnic identities there was a general correspondence with the geogra...
Our previous studies showed that further elucidation of the relationships among Northern European individuals was possible when analyses were performed excluding subjects of southern European origin. For the current study, we next examined Northern and Southern population groups separately and the effect of including or excluding different ethnic g...
To further explore the relationship of population groups in Europe, we also performed PCA including the HGDP South Asian groups, Burusho, and Balochi. These South Asian population groups showed relatively small population differentiation with continental European subjects (14,17,26,27). Thus inclusion of these populations might further suggest clin...
AIMs that discern population substructure are likely to be useful in candidate gene, chromosomal position-based association studies, and defining homogeneous subject sets (28). Our previous studies identified two sets of European substructure AIMs (ESAIMs): ns-ESAIMs and north-ESAIMs. The ns-ESAIMs separated European populations on a single axis (n...
To further assess the potential value and performance of ESAIMs we examined SNPs with large (10% to 25%) allele frequency differences between different European subgroups. The different subgroups were selected based on PCA results and included both individuals with self-identified ethnic affiliation and those without known self-identity information...
- Chao Tian, Roman Kosoy, Rami Nassir, Annette Lee, Pablo Villoslada, Lars Klareskog, Lennart Hammarst...
- 2009
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European population genetic substructure was examined in a diverse set of .1,000 individuals of European descent, each genotyped with .300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry.
Jul 4, 2008 · Abstract. Genetic structure in the European American population reflects waves of migration and recent gene flow among different populations. This complex structure can introduce bias in genetic association studies.
