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Jan 18, 2008 · The current study provides additional insight into European substructure and differences among different ethnic groups that may impact our understanding of the genetics of complex diseases.
- Chao Tian, Robert M Plenge, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Se...
- 2008
- Population Differentiation Among European Populations
- Principal Components Analyses Using >250,000 SNPs
- PCA of Northern and Southern European Population Groups
- PCA of European and South Asian Population Groups
- Identification and Testing of European Substructure Ancestry Informative Markers
- Performance of Esaims in Controlling For Population Substructure
To examine similarities and differences in population differentiation among European and closely related populations, paired Fst values were determined between 18 population groups that were typed with genome-wide SNP arrays (see Materials and Methods). The studies included genotypes derived from HGDP (14), and samples collected in Europe and Europ...
To further explore the relationship among European population groups and examine population substructure, PCA was performed using the genotype results from a set of ~300,000 autosomal SNPs that was common to each of the populations examined. For most individuals with self-reported ethnic identities there was a general correspondence with the geogra...
Our previous studies showed that further elucidation of the relationships among Northern European individuals was possible when analyses were performed excluding subjects of southern European origin. For the current study, we next examined Northern and Southern population groups separately and the effect of including or excluding different ethnic g...
To further explore the relationship of population groups in Europe, we also performed PCA including the HGDP South Asian groups, Burusho, and Balochi. These South Asian population groups showed relatively small population differentiation with continental European subjects (14,17,26,27). Thus inclusion of these populations might further suggest clin...
AIMs that discern population substructure are likely to be useful in candidate gene, chromosomal position-based association studies, and defining homogeneous subject sets (28). Our previous studies identified two sets of European substructure AIMs (ESAIMs): ns-ESAIMs and north-ESAIMs. The ns-ESAIMs separated European populations on a single axis (n...
To further assess the potential value and performance of ESAIMs we examined SNPs with large (10% to 25%) allele frequency differences between different European subgroups. The different subgroups were selected based on PCA results and included both individuals with self-identified ethnic affiliation and those without known self-identity information...
- Chao Tian, Roman Kosoy, Rami Nassir, Annette Lee, Pablo Villoslada, Lars Klareskog, Lennart Hammarst...
- 2009
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Sep 15, 2006 · Evidence for Major Difference in Population Structure of “Northern” and “Southern” Europe. For the analysis of population genetic structure, we first examined the 928 participants of European ancestry using a set of 2,657 SNPs in which the interval between each SNP was a minimum of 500 kilobases (kb) ( Figure 1 ).
- Michael F Seldin, Russell Shigeta, Pablo Villoslada, Carlo Selmi, Carlo Selmi, Jaakko Tuomilehto, Ga...
- 2005
Oct 22, 2009 · In this study, 1855 SLE cases of European descent were genotyped for 4965 single-nucleotide polymorphisms and principal components analysis of genotype information was used to define population...
- Ilana B. Richman, Sharon A. Chung, Kimberly E. Taylor, Roman Kosoy, Chao Tian, Ward A. Ortmann, Joan...
- 2010
Jul 30, 2009 · To determine whether genetic substructure in European-derived populations is associated with specific manifestations of systemic lupus erythematosus (SLE), including mucocutaneous phenotypes, autoantibody production, and renal disease. Methods.
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5 days ago · Articles | European Journal of Medical Research. Search by keyword. Search by citation. Page 1 of 47. Sort by. Twenty four-month follow-up after bullectomy, unilateral and bilateral lung volume reduction surgery: a single-center retrospective analysis of consecutive cases.
