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Apr 20, 2024 · Gerhard Domagk was a German bacteriologist and pathologist who was awarded the 1939 Nobel Prize for Physiology or Medicine for his discovery (announced in 1932) of the antibacterial effects of Prontosil, the first of the sulfonamide drugs. Domagk earned a medical degree from the University of Kiel
- The Editors of Encyclopaedia Britannica
5 days ago · Gerhard J. Domagk uses a chemically synthesized antimetabolite, Prontosil, to kill Streptococcus in mice. It is later shown that Prontosil is hydrolyzed in vivo to an active compound, sulfanilamide.
- Karen Yee
- 2018
6 days ago · Afterwards, Domagk became a researcher and clinician at the University of Munster. It was there that he developed the seeds of a major breakthrough when he utilized white blood cells coupled with a staph pathogen in his examination of the vertebrate immune system.
3 days ago · However, compared to the conventional microbiology, a higher sensitivity was calculated for sonication, albeit with a lower specificity in relation to a PJI. In two logistic regression models for the significance of all diagnostic parameters in PJI, the AUC was 0.92 and 0.96 with histology in particular making the decisive contribution in both ...
5 days ago · The Milestones in Microbiology designation is made in recognition of the long and productive history of significant contributions to the advancement of microbiology by University of Michigan microbial scientists.
- Karen Yee
- 2018
Apr 22, 2024 · The antibacterial effects of sulfonamides were first observed in 1932, when German bacteriologist and pathologist Gerhard Domagk noted the effects of the red dye Prontosil on Streptococcus infections in mice. It was later proved by French researchers that the active agent of Prontosil was sulfanilamide, or para- aminobenzenesulfonamide, a ...
May 6, 2024 · The first sulfonamide and the first systemically active antibacterial drug, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany, for which Domagk received the 1939 Nobel Prize in Physiology or Medicine.
