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Apr 2, 2013 · Preparation and analytical characterization of 1‐ (1‐phenylcyclohexyl)piperidine (PCP) and 1‐ (1‐phenylcyclohexyl)pyrrolidine (PCPy) analogues - Wallach - 2014 - Drug Testing and Analysis - Wiley Online Library.
- Jason Wallach, Giorgia De Paoli, Adeboye Adejare, Simon D. Brandt
- 2014
May 1, 1990 · Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues. | Semantic Scholar. DOI: 10.1021/JM00167A027. Corpus ID: 11849936. Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues. A. Thurkauf, B. de Costa, +4 authors. M. Rogawski. Published in Journal of Medicinal… 1 May 1990. Chemistry, Medicine. TLDR.
Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
Synthesis via imines: This is the best route for synthesis of compounds with mono N-alkyl substituents, such as PCE ( ref. 10 ). An intermediate imine is formed by the reaction of cyclohexanone and the appropriate primary amine. The phenyl group can then be introduced with phenyllithium ( ref 15, 16 ).
Planning a Synthesis using a Reductive Amination. If you are trying to develop a synthesis of an amine molecule, the key bond break is a C-N bond in the target molecule. There may be multiple C-N bonds present, so each should be broken separately to produce a possible set of starting materials.
Jan 1, 2016 · The first arylcyclohexamine to be described was 1-(1-phenylcyclohexyl) amine, in 1907, almost 50 years before the synthesis of PCP . Other analogues reported in the early 1950s included N -ethyl-1-phenylcyclohexylamine (PCE) and 1-(1-phenylcyclohexyl)morpholine (PCMo).
Feb 6, 2010 · Molecular weight: 175.2701. IUPAC Standard InChI: InChI=1S/C12H17N/c1-3-7-11 (8-4-1)13-12-9-5-2-6-10-12/h1,3-4,7-8,12-13H,2,5-6,9-10H2. IUPAC Standard InChIKey: TXTHKGMZDDTZFD-UHFFFAOYSA-N. CAS Registry Number: 1821-36-9. Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file.
