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1. analyticalsciencejournals.onlinelibrary.wiley.comPreparation and analytical characterization of...

   analyticalsciencejournals.onlinelibrary.wiley.com

   Apr 2, 2013 · Classic examples of psychoactive arylcycloalkylamines include ketamine and 1-(1-phenylcyclohexyl)piperidine (PCP) and many others serve as important structural templates for neuropharmacological research.

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2. chem.libretexts.org › Bookshelves › Organic_Chemistry24.6: Synthesis of Amines - Chemistry LibreTexts

   chem.libretexts.org › Bookshelves › Organic_Chemistry

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   Example. Planning a Synthesis using a Hoffman or Curtius Rearrangement. Because the amide and the acyl azide required for these rearrangements both are best made from an acid chloride, synthesis of amines using these reaction are best started from the corresponding carboxylic acid.

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   What are some examples of psychoactive arylcycloalkylamines?

   • Classic examples of psychoactive arylcycloalkylamines include ketamine and 1- (1-phenylcyclohexyl)piperidine (PCP) and many others serve as important structural templates for neuropharmacological research.

   Preparation and analytical characterization of 1‐(1‐phenylcyclohexyl

   analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.1468

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   What was the first arylcyclohexamine?

   • The first arylcyclohexamine to be described was 1- (1-phenylcyclohexyl) amine, in 1907, almost 50 years before the synthesis of PCP [ 1 ]. Other analogues reported in the early 1950s included N -ethyl-1-phenylcyclohexylamine (PCE) and 1- (1-phenylcyclohexyl)morpholine (PCMo).

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_124-1

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   What are arylcyclohexamines?

   • Arylcyclohexamines (also known as arylcyclohexylamines) are a group of compounds that contain a cyclohexamine unit with an aryl moiety, typically a phenyl ring, attached to the same atom to which the amine group is linked (see Fig. 1 ).

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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   What are the main effects of arylcyclohexamines?

   • Chemical structures of the primary arylcyclohexamines: phencyclidine , ketamine , and methoxetamine The main effects of this class of agents are nystagmus, hypertension, and tachycardia in a behaviorally disturbed, and possibly violent, patient.

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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4. chemistry.mdma.ch › hiveboard › rhodiumReaction Scheme III. Synthesis via imines: - chemistry.mdma.ch

   chemistry.mdma.ch › hiveboard › rhodium

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   Example: Synthesis of PCE (N-ethyl-1-phenylcyclohexylamine): A mixture of 100 g of anhydrous ethylamine and 220 g of cyclohexanone was kept 16 hours, then shaken with solid KOH. The lower oil layer, which comprises the imine ( N-cyclohexylidenethylamine), was then removed by decantation.

5. chemistry.mdma.ch › hiveboard › rhodiumUse of PCA (1-phenylcyclohexylamine) as a precursor

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   An attractive procedure from the standpoint of clandestine synthesis would be the reductive alkylation of PCA with acetone and aluminum amalgam to give the potent analog N-isopropyl phenylcyclohexylamine. The first method using PCA as an intermediate is Scheme IV.

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7. www.erowid.org › archive › rhodiumThe Synthesis of Phencyclidine and Other 1 ... - Erowid

   www.erowid.org › archive › rhodium

   The Synthesis of Phencyclidine and Other 1--4rylcyclohexylamines Received Juniiary 10, 1964 Revised Manuscripi Received October 2 $, 1!64 \-arious 1-arylcyclohesylaniiiies were synthesized fur evaliiatioii :ti ceiitral nervous system depressants. The compounds were prepared by several procedures.

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8. link.springer.com › referenceworkentry › 10Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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   Jan 1, 2016 · The most well-characterized arylcyclohexamines are phencyclidine ( (1- (1-phencyclohexyl) piperidine; PCP )), ketamine, and, of the novel analogues, methoxetamine. Chemical structures of the primary arylcyclohexamines: phencyclidine , ketamine , and methoxetamine.

9. www.semanticscholar.org › paper › Synthesis-andSynthesis and anticonvulsant activity of 1 ... - Semantic Scholar

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   May 1, 1990 · Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.