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4 days ago · Recent advances in the chemical and enzymatic synthesis of oligonucleotides that promise to transform the manufacturing landscape and enable a wider range of therapeutic applications are reviewed. Therapeutic oligonucleotides are a powerful drug modality with the potential to treat many diseases. The rapidly growing number of therapies that have been approved and that are in advanced clinical ...
19 hours ago · 7. Example - Anti-cancer medicines. Cancer is often treated with chemotherapy medicines that kill cells undergoing rapid growth (which most cancer cells do). One example of a semi-synthetically derived anti-cancer medicine is irinotecan, which is mainly used to treat colon cancer. Figure 1.2 Camptotheca acuminata (Link to the source)
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4 days ago · Herein, we report a silver-catalyzed protocol for decarboxylative cross-coupling between carboxylic acids and isocyanides, leading to linear amide products through a free-radical mechanism. The disclosed approach provides a general entry to a variety of decorated amides, accommodating a diverse array of radical precursors, including aryl, heteroaryl, alkynyl, alkenyl, and alkyl carboxylic ...
5 days ago · The synthesis of neuropeptides, like that of all proteins, requires the transcription of DNA and translation of the resulting messenger RNA (mRNA) into protein. Neuropeptides are synthesized as large precursor prepropeptides that undergo extensive posttranslational processing, which includes cleavages into smaller peptides and enzymatic ...
3 days ago · Kinesin spindle protein (KSP) inhibitors are one of the most promising anticancer agents developed in recent years. Herein, we report the synthesis of ispinesib-core pyridine derivative conjugates, which are potent KSP inhibitors, with half-sandwich complexes of ruthenium, osmium, rhodium, and iridium. Conjugation of 7-chloroquinazolin-4(3H)-one with the pyridine-2-ylmethylimine group and the ...
4 days ago · The key synthesis techniques for porphyrin-based MOFs, such as porphyrin@MOFs, porphyrinic MOFs, and composite porphyrinic MOFs, are outlined in this review article. This review article focuses on current advances and breakthroughs in the field of porphyrin-based MOFs for detecting a variety of targets (for example, metal ions, anions ...
1 day ago · To test our hypothesis, we conducted a comprehensive analysis of recent literature, exploring various green synthesis conditions and processes for Se NPs. Various characterisation techniques such as spectroscopy, microscopy and physicochemistry were discussed in order to provide insight into the formation and function of green-synthesised Se NPs.
