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The first step is the nucleophiic addition of ammonia, a 1 o amine, or a 2 o amine to a carbonyl group to form an imine (Section 19-8). The second step is the reduction of the imine to an amine using a hydride reducing agent.
2° amines. Then outline the synthesis of N-cyclopentyl-2-pentamine (also called N-pentylcyclopentanamine), using appropriate amine and ketone starting materials. Use “Raney Ni” as the reducing agent. Use the methods of section 20.4D to convert the amine in the last example into: N
3. Devise a synthesis of each of the following compounds using an arene diazonium salt. They all require more than one step and you may select the desired regioisomer (for example the para product from an ortho, para mixture) when needed. The answers to these problems can be found under the arene diazonium salts post.
thesis of 1-phenylcyclohexylamine. The compound prepared by the alternate route (method F) was identi- cal in all respects with the one obtained prepared from Method F aC6"I NCO - CxCeH5 "2 VI phenylcyclohexene. Recently, Cristol, et ul., re- ported the isolation of the amine as its benzoyl deriva- tive via a modified Ritter reaction.
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Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
Oct 14, 2021 · USA.gov. 1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
N-Phenylcyclohexylamine. Formula: C 12 H 17 N. Molecular weight: 175.2701. IUPAC Standard InChI: InChI=1S/C12H17N/c1-3-7-11 (8-4-1)13-12-9-5-2-6-10-12/h1,3-4,7-8,12-13H,2,5-6,9-10H2. Copy Sheet of paper on top of another sheet. IUPAC Standard InChIKey: TXTHKGMZDDTZFD-UHFFFAOYSA-N.
