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  1. 20 hours ago · Frederick is located in Frederick County in the northern part of the state of Maryland. The city has served as a major crossroads since colonial times. Today it is located at the junction of Interstate 70, Interstate 270, U.S. Route 340, U.S. Route 40, U.S. Route 40 Alternate and U.S. Route 15 (which runs north–south).

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