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- Season 5 overviewOct 2, 2016-May 21, 201724 episodesSeason 5 episodes1. Folie A Deux Oct 2, 2016
- Holmes and Watson assist the NYPD as they search for a serial bomber terrorizing the city.
- 2. Worth Several Cities Oct 16, 2016
- Holmes is abducted by the leader of a gang, who wants him to find out who's behind a hit on his men.
- 3. Render, and Then Seize Her Oct 23, 2016
- Capt. Gregson's girlfriend hires Holmes for a case she wants kept off from Gregson's radar.
- 4. Henny Penny the Sky Is Falling Oct 30, 2016
- Capt. Gregson tries to get Holmes and Watson included to receive a city commendation.
- 5. To Catch a Predator Predator Nov 6, 2016
- Holmes and Watson investigate the murder of a man who led a secret life as a vigilante.
- 6. Ill Tidings Nov 13, 2016
- A chef and his patrons are poisoned after consuming a menu item tainted with snake venom.
- 7. Bang Bang Shoot Chute Nov 20, 2016
- Holmes and Watson investigate after two killers target the same BASE jumper.
- 8. How the Sausage Is Made Nov 27, 2016
- Joan thinks Sherlock's sobriety is at risk; a man dies after eating poisoned sausage.
- 9. It Serves You Right to Suffer Dec 11, 2016
- Shinwell is framed for a gang killing and needs Holmes and Watson to find the real murderer.
- 10. Pick Your Poison Dec 18, 2016
- Watson is implicated in a DEA probe when her medical license is used to write illegal prescriptions.
- 11. Be My Guest Jan 8, 2017
- Holmes and Watson search for a kidnapped woman who's been held hostage for years.
- 12. Crowned Clown, Downtown Brown Jan 15, 2017
- Holmes and Watson discover a connection between a murder and the creation of a weaponized virus.
- 13. Over a Barrel Jan 29, 2017
- A man takes hostages to force Holmes to find the person responsible for the death of his son.
- 14. Rekt in Real Life Feb 19, 2017
- A former professional video game player dies after being assaulted during a live video stream.
- 15. Wrong Side of the Road Mar 5, 2017
- A killer is eliminating everyone involved with a case that Holmes previously worked on in London.
- 16. Fidelity Mar 12, 2017
- Joan and Kitty try to prove that a string of murders is connected to a government conspiracy.
- 17. The Ballad of Lady Frances Mar 19, 2017
- Investigating a homicide that was "heard" by a cutting-edge gunshot detection system.
- 18. Dead Man's Tale Mar 26, 2017
- Sherlock and Joan look into whether Shinwell may have gotten away with the murder of his friend.
- 19. High Heat Apr 16, 2017
- The duo probes the death of a man Sherlock considered one of New York's worst private investigators.
- 20. The Art of Sleights and Deception Apr 23, 2017
- Holmes and Watson investigate the death of a magician who dies while performing a classic stunt.
- 21. Fly Into a Rage, Make a Bad Landing Apr 30, 2017
- Watson and Holmes search for a suspect believed to be have committed two linked crimes.
- 22. Moving Targets May 7, 2017
- Holmes and Watson suspect a fellow competitor when a reality show contestant is murdered.
- 23. Scrambled May 14, 2017
- Holmes and Watson catch the attention of one of New York City's deadliest gangs.
- 24. Hurt Me, Hurt You May 21, 2017
- A gang war erupts in New York City as Holmes and Watson pursue an elusive criminal.