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May 4, 2022 · White matter disease is an umbrella term for damage to your brain’s white matter caused by reduced blood flow to the tissue. It can cause issues with memory, balance and mobility. People who have risk factors for cardiovascular disease also have a greater risk of developing white matter disease.
Apr 14, 2022 · White matter disease is the wearing away of tissue in the largest and deepest part of your brain that has a number of causes, including aging. This tissue contains millions of nerve fibers,...
Mar 21, 2023 · Major causes of periventricular white matter (PWM) lesions include normal changes from aging (then they are called UBO's, for "unidentified bright objects), small strokes, and disorders related to multiple sclerosis (MS).
Recent in vivo imaging studies provide supportive evidence that periventricular white matter lesions are associated with cortical cholinergic deafferentation in elderly with leukoaraiosis. White matter lesions at the frontal horns, so-called “capping,” are in close proximity to cholinergic axons that originate in the basal forebrain.
Changes in the white matter of presumed vascular origin were first identified as hypoattenuation of the white matter on computed tomography but now are more often seen as patchy areas of signal hyperintensity in deep and periventricular white matter areas on T2-weighted sequences, particularly fluid-attenuated inversion recovery.
MR scan of the brain typically shows patchy T2-weighted/fluid attenuated inversion recovery (FLAIR) signal changes in the periventricular and deep white matter, which become confluent over time with involvement of the pons, thalamus and basal ganglia.
MR-pathological studies of periventricular hyperintensity (leukoaraiosis) in aging and dementia reveal arteriolar tortuosity, reduced vessel density, and occlusive venous collagenosis which causes venous insufficiency and vasogenic edema.
Aug 10, 2022 · White matter hyperintensities (WMHs), characterized by bilateral and symmetrical hyperintensities on fluid-attenuated inversion-recovery imaging (FLAIR), are very common neuroradiological manifestations in the elderly (de Laat et al., 2011; Wardlaw et al., 2013; Graff-Radford et al., 2019 ).
Periventricular white matter is composed of bundles of myelinated nerve fibers (axons). These bundles appear “white” due to the heavy myelination of these fast-conducting fiber tracts, which convey motor and sensory information to their targets within the spinal cord and cerebrum, respectively.
Jan 30, 2024 · White matter disease, or leukoaraiosis, involves the degeneration of the brain’s white matter. White matter disease usually occurs due to aging, but it can also affect young people. Learn...
