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1. dermnetnz.org › topics › fixed-drug-eruptionFixed drug eruption | DermNet

   dermnetnz.org › topics › fixed-drug-eruption

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   Fixed drug eruption is a delayed type IV hypersensitivity reaction. In the initial phase memory CD8+ T-cells at the dermo- epidermal junction release interferon-gamma when activated by the medication antigen causing epidermal basal layer damage. Recruited T-cells and neutrophils damage melanocytes and keratinocytes.

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3. emedicine.medscape.com › article › 1336702-Fixed Drug Eruptions: Background, Pathophysiology, Etiology

   emedicine.medscape.com › article › 1336702-

   Oct 9, 2020 · The term fixed drug eruption (FDE) describes the development of one or more annular or oval erythematous patches as a result of systemic exposure to a drug; these reactions normally resolve with hyperpigmentation and may recur at the same site with reexposure to the drug. Repeated exposure to the offending drug may cause new lesions to develop ...

4. www.uptodate.com › contents › fixed-drug-eruptionFixed drug eruption - UpToDate

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   May 23, 2022 · INTRODUCTION. Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon re-exposure to the offending drug. Acute FDE usually presents with a single or a small number of dusky red or violaceous plaques that resolve leaving postinflammatory hyperpigmentation ( picture 1A-C ).

5. www.healthline.com › health › drug-rashDrug Rash and Eruption: Symptoms, Pictures, Causes, and Treatment

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   A drug rash or other reaction may occur for several reasons, such as: an allergic reaction. a buildup of the drug that causes toxicity to the skin. a drug makes the skin more sensitive to sunlight ...

6. www.ncbi.nlm.nih.gov › pmc › articlesA Review of Fixed Drug Eruption with a Special Focus on ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 1, 2021 · Fixed drug eruption (FDE) was first described in 1889 by Bourns, and the term fixed drug eruption, or “éruption érythémato-pigmentée fixe” was coined by Brocq in 1894 [1,2]. Brocq described “round or oval apparently edematous plaques, which varied in size from that of a coin to that of a palm; and which recurred on various parts of ...

   • Author: Hannah J Anderson, Jason B Lee
   • DOI: 10.3390/medicina57090925

   • Publish Year: 2021
   • Publication: Medicina (Kaunas). 2021 Sep; 57(9): 925.

7. People also ask

   What does a fixed drug eruption look like?

   • Fixed drug eruption typically presents as a single (or small number of) well-defined, round or oval red or violaceous patch or plaque which may blister or ulcerate. It is usually asymptomatic but can be itchy or painful.

   Fixed drug eruption | DermNet

   dermnetnz.org/topics/fixed-drug-eruption

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   How long does a fixed drug eruption last?

   • With the initial fixed drug eruption attack, a delay of up to 2 weeks may occur from the initial exposure to the drug to the development of the skin lesion. [ 47] Skin lesions develop over a period of hours but require days to become necrotic. Lesions may persist from days to weeks and then fade slowly to residual oval hyperpigmented patches.

   Fixed Drug Eruptions Clinical Presentation - Medscape

   emedicine.medscape.com/article/1336702-clinical

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   What is fixed drug eruption (FDE)?

   • Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD more... The term fixed drug eruption (FDE) describes the development of one or more annular or oval erythematous patches as a result of systemic exposure to a drug; these reactions normally resolve with hyperpigmentation and may recur at the same site with reexposure to the drug.

   Fixed Drug Eruptions: Background, Pathophysiology, Etiology - Medscape

   emedicine.medscape.com/article/1336702-overview

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   What is a fixed drug eruption érythémato-pigmentée fixe (FDE)?

   • Fixed drug eruption (FDE) was first described in 1889 by Bourns, and the term fixed drug eruption, or “éruption érythémato-pigmentée fixe” was coined by Brocq in 1894 [ 1, 2 ]. Brocq described “round or oval apparently edematous plaques, which varied in size from that of a coin to that of a palm; and which recurred on various parts of the body.

   A Review of Fixed Drug Eruption with a Special Focus on Generalized

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8468217/

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8. dermnetnz.org › images › fixed-drug-eruption-imagesFixed Drug Eruption Images — DermNet

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   A fixed drug eruption on the penile shaft due to a tetracycline - genital lesions are a common location for fixed drug eruptions. A fixed drug eruption on the cheek; it resolved to leave hyperpigmentation. A recurrent blistering lesion on the tongue - it arose within a day of ingesting cotrimoxazole on each occasion it was taken.

9. emedicine.medscape.com › article › 1336702-clinicalFixed Drug Eruptions Clinical Presentation - Medscape

   emedicine.medscape.com › article › 1336702-clinical

   Oct 9, 2020 · History. The initial eruption is often solitary and frequently located on the lip or genitalia. Rarely, the eruption may be intraoral. Other common locations of the initial lesion are the hip, lower back/sacrum, or proximal extremity. With the initial fixed drug eruption attack, a delay of up to 2 weeks may occur from the initial exposure to ...