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- Clindamycin works primarily by binding to the 50s ribosomal subunit of bacteria. This agent disrupts protein synthesis by interfering with the transpeptidation reaction, which thereby inhibits early chain elongation.
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May 23, 2023 · Mechanism of Action. Clindamycin prevents peptide bond formation, thereby inhibiting protein synthesis by reversibly binding to 50S ribosomal subunits. Depending on the organism, infection site, and drug concentration, clindamycin may be a bacteriostatic or bactericidal antibiotic.
- 2023/05/23
Jan 11, 2023 · mechanism of action Clindamycin works primarily by binding to the 50s ribosomal subunit of bacteria. This agent disrupts protein synthesis by interfering with the transpeptidation reaction, which thereby inhibits early chain elongation.
Mechanism of action. Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S subunit of the bacterial ribosome. 14 It impedes both the assembly of the ribosome and the translation process. 20 The molecular mechanism through which this occurs is thought to be due to clindamycin's three-dimensional structure, which ...
The topically used clindamycin phosphate is a phosphate-ester prodrug of clindamycin. Mechanism of action Clindamycin mechanism. Clindamycin has a primarily bacteriostatic effect. At higher concentrations, it may be bactericidal.
- C₁₈H₃₃ClN₂O₅S
- Cleocin, Clinacin, Dalacin, others
- AU: A
- Liver
Adverse Effects. Dosing Considerations. Clindamycin is a lincosamide antibiotic that is primarily bacteriostatic. It binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis. Pharmacokinetics. Clindamycin is absorbed well orally and can be given parenterally.
It works by slowing or stopping the growth of bacteria. Antibiotics such as clindamycin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. How should this medicine be used?
Indications. Contraindications. Use During Pregnancy and Breastfeeding. Adverse Effects. Dosing Considerations. Clindamycin is a lincosamide antibiotic that is primarily bacteriostatic. It binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis. Pharmacokinetics.
