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May 16, 2019 · Von Willebrand disorder type I (vWDI) is known as an inherited bleeding disorder in different dog breeds following an autosomal recessive inheritance. The Kromfohrländer is a rare dog breed with an increased incidence of unclear bleeding episodes and prolonged coagulation time during/after surgery or injuries, indicating a defect in one or more critical proteins of the coagulation cascade.
- Julia H. Segert, Jana-Marie Seidel, Walter J. Wurzer, Anja M. Geretschlaeger
- 2019
Keywords: Von Willebrand disease, Von Willebrand factor, Genetic disorder, Genetic testing, Kromfohrländer Plain english summary A variety of bleeding diseases are known in dogs includ-ing von Willebrand disease type I. This genetic disorder affects the von Willebrand factor in plasma which is important for blood clotting. A genetic mutation known
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Is von Willebrand disease inherited in Kromfohrländer dogs?
What is von Willebrand's disease in dogs?
Is Kromfohrländer a von Willebrand type 1 mutation?
VWD is caused by genetic changes that are almost always inherited (passed down) from a parent to a child. A person’s genes provide instructions on how to make proteins, such as the von Willebrand factor (VWF) protein. Each person has two copies of most genes, one from his or her mother and one from his or her father. Each copy is called an ...
Dec 17, 2021 · Canine von Willebrand disease (vWD) Von Willebrand disease (also referred to as von Willebrand’s disease) is an inherited bleeding disorder commonly seen in both dogs and humans. vWD is characterized by an insufficient production of a protein, called von Willebrand factor (vWF). vWF helps blood cells (called platelets) stick together, forming ...
Von Willebrand's disease is the most common inherited bleeding disorder of dogs occurring with particularly high frequency in Doberman pinscher dogs. Because of its method of transmission (autosomal incomplete dominant), the clinical and laboratory severity of the disease varies considerably.
- Johnstone Ib
- 1986
The G > A mutation in the VWF gene in the Kromfohrländer breed and the subsequent vWDI is found as the underlying cause for the bleeding episodes and delayed coagulation in heterozygous and homozygous dogs. Von Willebrand disorder type I (vWDI) is known as an inherited bleeding disorder in different dog breeds following an autosomal recessive ...
Von Willebrand’s disease (vWD) is a common, usually mild, inherited bleeding disorder in people and in dogs. It is caused by a lack of von Willebrand factor (vWF), which plays an essential role in the blood clotting process. Normally the body responds to an injury causing bleeding through a complex defense system.
