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Nov 24, 2016 · Von Willebrand's disease is the most common inherited bleeding disorder and is generally transmitted as an autosomal dominant trait. ... 45,50 Some authors have proposed that an increase ...
Specialty. Hematology. Von Willebrand disease ( VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion.
- .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}/ˌfʌnˈvɪlɪbrɑːnt/
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What is von Willebrand disease?
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Synopsis. Von Willebrand disease (VWD) is a common bleeding disorder, affecting males and females equally, that often manifests in mucosal bleeding. VWD can be secondary to a quantitative (Type 1 and Type 3) or qualitative (Type 2) defects in Von Willebrand factor.
- Angela C. Weyand, Veronica H. Flood
- 2021/12
- 10.1016/j.hoc.2021.07.004
Print. Von Willebrand disease (VWD) is a blood disorder in which the blood does not clot properly. Blood contains many proteins that help the blood clot when needed. One of these proteins is called von Willebrand factor (VWF). People with VWD either have a low level of VWF in their blood or the VWF protein doesn’t work the way it should.
Oct 26, 2021 · If you have von Willebrand disease, you might have: Excessive bleeding from an injury or after surgery or dental work. Frequent nosebleeds that don't stop within 10 minutes. Heavy or long menstrual bleeding. Heavy bleeding during labor and delivery. Blood in your urine or stool. Easy bruising or lumpy bruises.
The Diagnosis, Evaluation and Management of von Willebrand Disease. Published Jan 2008. Download PDF 2 MB. This report provides the complete and authoritative presentation on the causes, diagnosis and treatment of the common, inherited bleeding disorder known as von Willebrand Disease. This is the first-ever evidence-based presentation by NHLBI ...
Apr 29, 2021 · von Willebrand disease (VWD) is an inherited bleeding disorder resulting from quantitative or qualitative deficiencies in von Willebrand factor (VWF), a plasma multimeric glycoprotein controlling platelet adhesion and aggregation. 1 Although VWD is expected to affect men and women equally, there are more women diagnosed with VWD because of gynecological-related hemostatic challenges.
