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What is a norepinephrine transporter?
Which ion-dependent transporter is responsible for norepinephrine transport in glial cells?
Which neurotransmitter transports norepinephrine and dopamine?
Where is the norepinephrine transporter gene located?
The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene. [5] NET is a monoamine transporter and is responsible for the sodium-chloride (Na + /Cl − )-dependent reuptake of extracellular norepinephrine (NE), which is also ...
Inside the brain norepinephrine functions as a neurotransmitter and neuromodulator, and is controlled by a set of mechanisms common to all monoamine neurotransmitters. After synthesis, norepinephrine is transported from the cytosol into synaptic vesicles by the vesicular monoamine transporter (VMAT).
- C₈H₁₁NO₃
- dopamine
- 169.180 g·mol−1
The three major classes are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrine transporters (NETs) and are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, and norepinephrine).
Chapters and Articles. Norepinephrine Transporter. Simi Vincent, in Encyclopedia of Endocrine Diseases, 2004. Transporters. Vesicular Monoamine Transporter. NE taken up into the presynaptic neuron by norepinephrine transporter (NET) (Uptake 1) is translocated into storage vesicles or deaminated by monoamine oxidase.
May 1, 2023 · The steps for norepinephrine synthesis are as follows: Tyrosine is first hydroxylated to dihydroxyphenylalanine (DOPA) by tyrosine hydroxylase (rate-limiting step). DOPA is then decarboxylated by L-amino acid decarboxylase to produce dopamine.
- Laila S. Hussain, Vamsi Reddy, Christopher V. Maani
- CUSOM, McKinsey & Company, US Army
- 2019
- 2023/05/01
Jan 7, 2020 · The norepinephrine transporter (NET) belongs to the family of sodium-coupled ion-dependent transporters (SLC6). In high density NET occurs in the plasma membranes of noradrenergic neurons and also in glial cells . It is physiologically responsible for norepinephrine (NE) transport from the synaptic cleft into presynaptic neurons .
Apr 13, 2021 · Norepinephrine is a biogenic amine neurotransmitter that has widespread effects on alertness, arousal and pain sensation. Consequently, blockers of norepinephrine uptake have served as vital...
