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The norepinephrine transporter ( NET ), also known as noradrenaline transporter ( NAT ), is a protein that in humans is encoded by the solute carrier family 6 member 2 ( SLC6A2) gene. [5] NET is a monoamine transporter and is responsible for the sodium-chloride (Na + /Cl − )-dependent reuptake of extracellular norepinephrine (NE), which is ...
Neurotransmitter transporters are a class of membrane transport proteins that span the cellular membranes of neurons. Their primary function is to carry neurotransmitters across these membranes and to direct their further transport to specific intracellular locations. There are more than twenty types of neurotransmitter transporters.
NET is a monoamine transporter and is responsible for the sodium-chloride (Na + /Cl − )-dependent reuptake of extracellular norepinephrine (NE), which is also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft.
Abstract. The norepinephrine transporter (NET) is situated in the presynaptic plasma membrane of noradrenergic neurons; this receptor is responsible for ∼90% of the norepinephrine (NE) uptake that is released in the synaptic cleft. Many antidepressants block this receptor, resulting in potentiation of NE actions in pre- and postsynaptic ...
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Where is the norepinephrine transporter located?
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The norepinephrine transporter (NET), present on the plasma membrane of noradrenergic neurons, limits the action of NE through reuptake into the cytoplasm. The NET not only regulates the longevity of NE in the synapse but also plays a very important role in presynaptic and postsynaptic homeostasis ( Axelrod and Kopin 1969 ; Iversen 1971 ; Xu et ...
Apr 13, 2021 · The Drosophila dopamine transporter (dDAT) is a catecholamine neurotransmitter transporter that resembles the human norepinephrine transporter (hNET). Here the authors report X-ray structures ...
