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  1. Depart from various cities, including Miami or Los Angeles, and cruise to some of the most exotic and beautiful destinations on Earth. Discover for yourself why Norwegian is the Best Cruise Line in Panama Canal & Central America according to Cruise Critic. 50% OFF.

  2. Panama Canal from Tampa, FL. 1 cruises from. $. 1389. *. Avg PP. See Cruises. * Taxes, fees, and port expenses are additional per person. Take a cruise with Carnival through the iconic Panama Canal and stop in ports like Cartagena, Puerto Quetzal, and Puntarenas.

  3. Panama Canal Cruises. Experience one of the wonders of the modern world on Holland America Line’s Panama Canal cruises. Our Panama cruise itineraries depart from both east and west coasts for loads of convenient options.

  4. Celebrity offers a variety of Panama Canal cruises, with several different ports of call. You could sail from Fort Lauderdale to the ABC Islands (Aruba, Bonaire, and Curacao) and Cartagena in Colombia. A sailing from Miami to Los Angeles visits Cartagena, Puntarenas in Costa Rica, and Puerto Vallarta.

  5. Discover all you need to cruise to Panama Canal (Cruising), Panama. Visit to get information on Panama Canal (Cruising), Panama cruises, including things to do, dining, ports of call, cruise ships, shore excursions, offers, and more.

  6. The Leader in the Panama Canal Cruise Ports. From ships custom built to sail the massive locks to immersive onboard programs and onshore adventures that inspire, Princess is the number one way to explore this epic phenomenon. We've sailed the Panama Canal since 1967 and we have more itinerary choices and departures of any cruise line in the region.

  7. The Panama Canal cruise season runs from October to April. The best time to go is after the rainy season ends in November. Panama Canal Cruise Lines. Most of the major lines and some...

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