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Clayton Pierce (William McNamara), an intelligence agent, is trailing a big drug case, but he loses his cover and is wounded in the process. After he reports to his superior, Agent La Nova (Roy Scheider), Clayton starts to find his memory failing. Eventually, he discovers that his agency has subjected him to an experimental drug called Oblivion that is eroding his memory. Now, Clayton must track down both his intelligence targets and his own team to discover how to reverse his condition.