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  1. Such popular brands include: Nytol: This OTC sleep aid typically contains diphenhydramine as the active ingredient, which is known for its sedative effect. Sominex: Another OTC brand containing ...

  2. Jun 8, 2022 · Sleep aids: The options. Sleep aids available without a prescription are widely available. Common choices and the potential side effects include: Diphenhydramine (Benadryl). Diphenhydramine is a sedating antihistamine. Side effects might include daytime drowsiness, dry mouth, constipation and urinary retention. Doxylamine (Unisom).

  3. Jan 30, 2019 · Antihistamines. Common sleep meds like Zzzquil and Unisom contain antihistamines like diphenhydramine and doxylamine as the active ingredients. (The allergy medication Benadryl also contains ...

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