Jul 14, 2020 · "The inhibitor binds four capsid molecules to form a tetramer. Such capsid tetramers are assembled into dengue virus," said Mark White, Associate Professor at UTMB who co-senior authored the study.
Jul 24, 2020 · Mechanism When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. It binds to and enters white blood cells, and reproduces inside the cells while they move throughout the body.
Jul 13, 2020 · July 13, 2020. GALVESTON, Texas – A multidisciplinary team from The University of Texas Medical Branch at Galvestonhas uncovered a new mechanism for designing antiviral drugs for dengue virus. The study is currently available in Proceedings of the National Academy of Sciences. Dengue virus is a very important mosquito-transmitted viral pathogen, causing 390 million human infections each year.
Jul 13, 2020 · Researchers at the University of Texas Medical Branch at Galveston have uncovered a new antiviral mechanism for the new dengue virus. Findings were published in Proceedings of the National Academy of Sciences. The dengue virus is a mosquito-transmitted pathogen leading to 390 million human infections annually.
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Jul 14, 2020 · The results have uncovered an antiviral mechanism through inhibitor-induced tetramerization of the viral capsid and provided essential structural and functional knowledge for rational design of panserotype DENV capsid inhibitors. DENV represents the most important mosquito-borne viral pathogen in humans. Although one dengue vaccine has been approved for clinical use, its efficacies against serotypes 1 and 2 remain to be improved.
- Hongjie Xia, Xuping Xie, Jing Zou, Christian G. Noble, William K. Russell, Luis Marcelo F. Holthauze...
Jul 23, 2020 · Scientists Uncover Mechanism Behind Development of Viral Infections July 16, 2019 — A team of researchers found that immune cells undergoing stress and an altered metabolism are the reasons why...
Jul 31, 2020 · Abstract Viruses manipulate the life cycle in host cells via the use of viral properties and host machineries. Development of antiviral peptides against dengue virus (DENV) infection has previously...
5 days ago · The virus binds to the antigen-binding site at the other end, and in this way gains entry to and infects the immune cell. Dengue virus can use this mechanism to infect human macrophages, if there was a preceding infection with a different strain of the virus, causing a normally mild viral infection to become life-threatening.
Jul 29, 2020 · The bacterial endosymbiont Wolbachia is a biocontrol tool that inhibits the ability of the Aedes aegypti mosquito to transmit positive-sense RNA viruses such as dengue and Zika. Growing evidence indicates that when Wolbachia strains w Mel or w AlbB are introduced into local mosquito populations, human dengue incidence is reduced.
6 days ago · New Mechanism for Identifying Drugs for Dengue Discovered New mechanism for designing antiviral drugs for dengue virus has been identified. The study details are published in Proceedings of the...
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