Search results
May 3, 2019 · No treatment: No specific antiviral agents exist for dengue. Supportive care is advised: Patients should be advised to stay well hydrated and to avoid aspirin (acetylsalicylic acid), aspirin-containing drugs, and other nonsteroidal anti-inflammatory drugs (such as ibuprofen) because of their anticoagulant properties. Fever should be controlled ...
Jun 2, 2022 · Dengue - Questions and Answers. 2 June 2022. Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue. The incidence of dengue has increased 30-fold over the last 50 years. Up to 50-100 million infections are now estimated to occur annually in over ...
Dengue is caused by infection with 1 of the 4 serotypes of dengue virus, which is a Flavivirus (a genus of single-stranded nonsegmented RNA viruses). Infection with one dengue serotype confers lifelong homotypic immunity to that serotype and a brief period (approximately 2 years) of partial heterotypic immunity to other serotypes, but an ...
Jan 9, 2014 · The mechanisms underlying severe dengue disease are currently being investigated by several research groups, identifying components that are essential for dengue-induced immune enhancement. The imbalanced and deregulated cell-mediated immunity is a pivotal component. 10 – 16 In this phenomenon, DENV infection of dendritic cells strongly ...
Mar 8, 2023 · Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics.
Feb 17, 2022 · Abstract. Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins. Four of the seven nonstructural proteins, NS2A, NS2B, NS4A and NS4B, are membrane ...
Sep 16, 2021 · Moreover, the limited number of studies also hinders the identification of the underlying mechanism(s) of vaccine efficacy for developing a universal dengue virus. Clinical trials with a leading candidate vaccine demonstrated that unbalanced replication and immunodominance of one vaccine component over others may result in low efficacy and ...
