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Sep 20, 2019 · In this chapter we will discuss the evolution of virus and its vector, epidemiology of dengue, molecular and genomic structure of DENV, their pathogenesis, immune response of the host to the infection, laboratory diagnosis, management, and recent developments in dengue drug and vaccine development.
Like other viruses, the dengue virus is a microscopic structure that can only replicate inside a host organism. Who discovered the dengue virus? How many types of dengue viruses are...
The DENV genome is about 11000 bases of positive-sense, single-stranded RNA (ssRNA) that codes for three structural proteins (capsid protein C, membrane protein M, envelope protein E) and seven nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). [4]
The dengue virus has a roughly spherical structure. It is composed of the viral genome and capsid proteins surrounded by an envelope and a shell of proteins. After...
Mar 3, 2002 · We report the structure of dengue virus type 2 S1 strain, a vaccine candidate derived from the PR-159 isolate (Hahn et al., 1988). A three-dimensional image reconstruction shows that the virion has a well-organized outer protein shell, a lipid bilayer membrane, and a less-well-defined inner nucleocapsid core.
Aug 30, 2013 · Dengue is an acute febrile disease caused by the mosquito-borne dengue viruses (DENVs), consisting of four serotypes (DENV 1 to 4), that are members of the family, genus flavivirus (1). All four DENV serotypes have emerged from sylvatic strains in the forests of South-East Asia (2).
Oct 1, 2023 · Genomic structure of dengue virus (created in Biorender). This dengue is structured in an icosahedral shape and has an envelope formed by a layer of protein at its outer core. The icosahedral core is forty to fifty nanometers in diameter and has a C-protein viral genome.
Abstract. Dengue is a vector-borne viral disease caused by the flavivirus dengue virus (DENV). Approximately 400 million cases and 22 000 deaths occur due to dengue worldwide each year. It has been reported in more than 100 countries in tropical and subtropical regions.
Mar 29, 2019 · Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus function.
May 17, 2021 · We showed how the RNA secondary structure can be used to categorise viruses, and even to further classify them based on the interaction with proteins. We envision that these approaches can be used to further classify and characterise these complex viruses.
