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11 hours ago · Dengue virus (DENV) is a continuing global threat that puts half of the world’s population at risk for infection. This mosquito-transmitted virus is endemic in over 100 countries. When a mosquito takes a bloodmeal, virus is deposited into the epidermal and dermal layers of human skin, infecting a variety of permissive cells, including keratinocytes, Langerhans cells, macrophages, dermal ...
3 days ago · The flavivirus NS1 gene encodes a highly conserved, 352–amino acid glycoprotein with a molecular weight of 46 to 55 kDa depending on its glycosylation status ().NS1 is initially synthesized in the cytoplasm as a soluble monomer, undergoes posttranslational modification in the endoplasmic reticulum (ER) and the trans-Golgi network, and rapidly dimerizes with subsequent transport to the cell ...
4 days ago · The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. ... J.-H. et al. USP18 enhances dengue virus replication by regulating ...
1 day ago · Dengue virus, a single-stranded positive-sense RNA virus belonging to Flaviviridae family within the Orthoflavivirus genus, is responsible for causing dengue (1). Bangladesh has been experiencing Dengue outbreaks every year since 2000. But the 2023 outbreak surpassed all previous records with 321,179 hospitalized cases including 1,705 deaths (2). In 2023, Dengue serotype 2 replaced the ...
3 days ago · The increasing burden of dengue virus on public health due to more explosive and frequent outbreaks highlights the need for improved surveillance and control. Genomic surveillance of dengue virus not only provides important insights into the emergence and spread of genetically diverse serotypes and genotypes, but it is also critical to monitor the effectiveness of newly implemented control ...
4 days ago · Updated: Apr 30 2024 1:00AM. In the Region of the Americas, the total number of cases of arboviral disease reported in 2021 as of 52 represents approximately 41.8 % relative decrease compared to the same period in 2020. It is worth noting that in 2021 dengue peaked at EW 14, whereas chikungunya peaked in EW 22.
5 days ago · The dengue illness is characterized by three phases: (1) febrile phase is between the 1st and 3rd day of onset; (2) critical phase is during the 4th to 6th day of onset; (3) recovery phase is after the 7th day of onset. 18. The healthy individuals included three females and five males.
