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Introduction. Once a pain signal from the ascending pathway reaches the somatosensory cortex, it triggers the descending pain modulatory system. The goal of this pathway is to allow the organism to function enough to respond to the pain source by reducing the pain signal through neuronal inhibition ie the "top down" modulation of pain.
Jul 24, 2018 · The pathway that goes upward carrying sensory information from the body via the spinal cord towards the brain is defined as the ascending pathway, whereas the nerves that goes downward from the brain to the reflex organs via the spinal cord is known as the descending pathway.
- Mun Fei Yam, Yean Chun Loh, Chu Shan Tan, Siti Khadijah Adam, Nizar Abdul Manan, Rusliza Basir
- 10.3390/ijms19082164
- 2018
- Int J Mol Sci. 2018 Aug; 19(8): 2164.
Descending pain facilitatory and inhibitory circuits arising ultimately in the brainstem provide mechanisms that can be engaged to promote or protect against pain ‘chronification’. These systems interact with higher centres, thus providing a means through which exogenous factors can influence the risk of pain chronification.
- Michael H. Ossipov, Kozo Morimura, Frank Porreca
- 2014
We describe the organization of several ascending nociceptive pathways, including the spinothalamic, spinomesencephalic, spinoreticular, spinolimbic, spinocervical, and postsynaptic dorsal column pathways in some detail and discuss nociceptive processing in the thalamus and cerebral cortex.
- W D Willis, K N Westlund
- 10.1097/00004691-199701000-00002
- 1997
- 1997/01
Mar 4, 2019 · The goal of the review was to highlight recent advances in our understanding of descending pain-modulating systems and how these contribute to persistent pain states, with an emphasis on the current state of knowledge around “bottom-up” (sensory) and “top-down” (higher structures mediating cognitive and emotional processing) influences on pain-m...
- Qi Liang Chen, Mary M. Heinricher
- 2019
Nov 26, 2018 · The descending pain pathway is a critical modulator of nociception and plays an important role in mediating endogenous and exogenous opioid-induced analgesia. Because of this, it is highly implicated in allostatic cellular and molecular changes following repeated opioid use that lead to the development of tolerance.
Oct 1, 2019 · This review summarises the most recent findings in the field relating to the influence and impact of descending modulatory controls on pain perception. Bottom-up nociceptive drive. There is a weight of influence of primary afferent activation on descending pathway activity.
