Structure. The nucleus accumbens is an aggregate of neurons which is described as having an outer shell and an inner core. Input. Major glutamatergic inputs to the nucleus accumbens include the prefrontal cortex (particularly the prelimbic cortex and infralimbic cortex), basolateral amygdala, ventral hippocampus, thalamic nuclei (specifically the midline thalamic nuclei and intralaminar nuclei ...
Jul 23, 2019 · The nucleus accumbens is involved in the brain's reward circuit and behavior mediation. Globus Pallidus: These paired nuclei (one in each hemisphere) are located near the caudate nucleus and putamen. The globus pallidus is divided into internal and external segments and acts as one of the major output nuclei of the basal ganglia.
The release of dopamine from the mesolimbic pathway into the nucleus accumbens regulates incentive salience (e.g. motivation and desire for rewarding stimuli) and facilitates reinforcement and reward-related motor function learning; it may also play a role in the subjective perception of pleasure.
Mar 11, 2010 · Here, we show an enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstinence from alcohol but not sucrose self-administration. Increased firing is associated with reduced small-conductance calcium-activated potassium channels (SK) currents and decreased SK3 but not SK2 subunit protein expression.
Jul 05, 2022 · Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role in motivated behaviors and associated disorders. However, while the activation of ChIs has been well studied in the dorsal striatum, little is known about how they are engaged in the NAc.
Mar 15, 2019 · In contrast, inactivation or lesion of the nucleus accumbens core in sign- and goal-tracking rats does not have any evident effect on behavior (Fraser & Janak 2017, Chang, Wheeler, & Holland 2012, Blaiss & Janak 2009), suggesting that maybe neural activity isn't essential in this region but dopaminergic modulation is.
May 20, 2022 · A significant loss of large neurons in the basal nucleus was observed in patients with Alzheimer's disease. Nucleus accumbens is located at the junction of the putamen and the tail of the nucleus caudatus. The nucleus accumbens integrates and reconciles information from the extrapyramidal and limbic systems.