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The term morbilliform refers to a rash that looks like measles. [1][2] The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places. [3] A morbilliform rash is a rose-red flat (macular) or slightly elevated (maculopapular) eruption, showing circular or elliptical lesions varying in diameter ...
- What Is Morbilliform Drug reaction?
- Who Gets Morbilliform Drug Eruption?
- What Causes Morbilliform Drug Eruption?
- What Are The Clinical Features of Morbilliform Drug Eruption?
- What Are The Complications of Morbilliform Drug Eruption?
- How Is Morbilliform Drug Eruption Diagnosed?
- What Is The Treatment For Morbilliform Drug Eruption?
- How Can Morbilliform Drug Eruption Be Prevented?
- What Is The Outlook For Morbilliform Drug Eruption?
Morbilliform drug eruption is the most common form of drug eruption. Many drugs can trigger this allergic reaction, but antibiotics are the most common group. The eruption may resemble exanthems caused by viral and bacterial infections. 1. A morbilliform skin rashin an adult is usually due to a drug. 2. In a child, it is more likely to be viral in ...
About 2% of prescriptions of new drugs cause a drug eruption. About 95% of these are morbilliform drug eruptions. They mainly affect people prescribed beta-lactam antibiotics (penicillins, cephalosporins), sulfonamides, allopurinol, anti-epileptic drugs and nonsteroidal anti-inflammatory drugs (NSAID). Numerous other drugs have been reported to cau...
Morbilliform drug eruption is a form of allergic reaction. It is mediated by cytotoxic T-cells and classified as a Type IV immune reaction. The target of attack may be drug, a metabolite of the drug, or a protein bonded to the drug. Inflammation follows the release of cytokines and other effector immune cells.
On the first occasion, a morbilliform rash usually appears 1–2 weeks after starting the drug, but it may occur up to 1 week after stopping it. On re-exposure to the causative (or related) drug, skin lesionsappear within 1–3 days. It is very rare for a drug that has been taken for months or years to cause a morbilliform drug eruption. Morbilliform d...
In the early phase, it may not be possible to clinically distinguish an uncomplicated morbilliform eruption from other more serious cutaneous adverse reactions(SCAR). These are: 1. Drug hypersensitivity syndrome 2. Stevens Johnson syndrome – toxic epidermal necrolysis(SJS/TEN) 3. Acute generalised exanthematous pustulosis (AGEP) Patients with the f...
A strong clinical suspicion of morbilliform drug eruption depends on: 1. Typical exanthematous rash 2. Recently introduced medication To identify the possible causative drug, a drug calendar, including all prescribed and over-the counter products, may be helpful. The starting date of each new drug is documented together with the onset of the rash. ...
The most important thing is to identify the causative drug and if possible, stop it. If the reaction is mild, and the drug is essential and not replaceable, obtain a specialist opinion whether it is safe to continue the drug before doing so. 1. Monitor the patient carefully in case of complications. 2. Apply emollients and potent topical steroid cr...
It is not possible to completely prevent morbilliform eruptions. Prescribers must be vigilant. Their incidencemay be reduced by: 1. Minimising prescriptions for antibiotics 2. Educating the patient about the cause of their rash and the danger of re-exposure to the same medication 3. Adding the reaction to the medical record alerts
If the causative drug is ceased, the rash begins to improve within 48 hours and clears within 1–2 weeks. If the drug is continued, the rash may: 1. Resolve despite continued exposure to the drug 2. Persistwithout change 3. Progress to erythroderma
Jan 12, 2023 · Exanthematous (maculopapular) drug eruption, also called morbilliform (measles-like) drug-induced exanthem, is the most common drug hypersensitivity reaction [1,2]. It is characterized by a disseminated, and occasionally generalized, symmetric eruption of erythematous macules and/or papules (picture 1A-B) that occur approximately one to two ...
Jul 21, 2020 · Of the 88 patients analyzed, cutaneous manifestations observed were: erythematous rash (14 patients), widespread urticaria (three patients), and chickenpox like vesicles (one patient). These rashes mainly involved the trunk, were seldom present with pruritus, and resolved within a few days.
- Radhika B Kulkarni, Yitzchok Lederman, Agura Afiari, Jacqueline A Savage, Jason Jacob
- 10.7759/cureus.9321
- 2020
- Cureus. 2020 Jul; 12(7): e9321.
Many viral illnesses and medicines can cause a measles-like rash known as a morbilliform rash. Learn the causes, symptoms, and when to call a doctor.
WHO reported a surge in cases worldwide in 2018, with nearly 10 million cases, and more than 140,000 deaths mostly in children under 5 years of age. The highest incidence rates were in the Ukraine, Somalia, Democratic Republic of Congo, Liberia and Madagascar.
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Jul 18, 2023 · 5.1. Morbilliform (Maculopapular) Eruption. The morbilliform eruption is the most commonly observed cutaneous irAE. It affects approximately 49–68% of patients undergoing anti-CTLA-4 therapy and 20% of patients receiving PD-1/PD-L1 inhibitors [13, 47].
