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  1. Jan 1, 2022 · Definition. Nucleus accumbens (NAc) is a brain area found in basal forebrain. It is present in between caudate and putamen nuclei of basal ganglia. NAc is also the main component of ventral striatum. Most importantly NAc is implicated in reward pathway of brain.

  2. Oct 18, 2019 · The nucleus accumbens (NAc) is a subcortical brain structure known primarily for its roles in pleasure, reward, and addiction. Despite less focus on the NAc in pain research, it also plays a large role in the mediation of pain and is effective as a source of analgesia.

  3. A target of increasing interest is the nucleus accumbens (NAc), which has long been studied as a key brain region mediating a variety of behaviors, including reward and satisfaction. As such, focal modulation of the biology of the NAc with deep brain stimulation or novel biological therapies such as gene therapy or cell transplantation could ...

  4. The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action. Stan B. Floresco 1. View Affiliations. Vol. 66:25-52 (Volume publication date January 2015) https://doi.org/10.1146/annurev-psych-010213-115159. First published as a Review in Advance on September 17, 2014. © Annual Reviews. info Info. list Sections. PDF. build Tools.

  5. Jul 22, 2022 · PMID: 35901682. DOI: 10.3171/2022.5.JNS212548. Abstract. Objective: The nucleus accumbens (NAcc) of the ventral striatum is critically involved in goal- and reward-based behavior. Structural and functional abnormalities of the NAcc or its associated neural systems are involved in neurological and psychiatric disorders.

  6. The nucleus accumbens may play an important role in behaviors related to addiction and chronic pain. Recent observations in addicted humans likewise reinforce the concept that the nucleus accumbens is a gratification site. These patients show marked binding of substances to cells in nucleus accumbens.

  7. Jan 29, 2024 · The nucleus accumbens (NAc), a central structure in the mesolimbic reward pathway, integrates the salience of aversive and rewarding stimuli. Despite extensive research on dHPC→NAc direct...

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