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2 days ago · Recent preclinical studies suggested that the amygdala (AMY) is a complex and heterogeneous group of nuclei, whose specific connectivity could drive different emotional valences [1, 2].Numerous ...
2 days ago · Recently, RNA-sequencing of astrocyte-specific mRNA collected from mice across time of day revealed that astrocytes in the nucleus accumbens (NAc) express robust rhythms in canonical clock genes, and impressively, nearly half of the astrocyte transcriptome exhibits significant diurnal rhythmicity
1 day ago · “Through our work, we have also established a landmark dataset that integrates drug-induced brain-wide neural activation with input circuit mapping from the nucleus accumbens, which could be useful to the broad scientific community conducting substance use disorder research,” says Bowen Tan, the other co-first author of the study, and a ...
1 day ago · In TNP, alteration in dopaminergic neurotransmission circuitry affects multiple brain regions such as IC and nucleus accumbens core (NAcc). Since IC has output projections towards NAcc and NAcc modulation have been found to be involved in TNP, IC dopaminergic neurotransmission can influence TNP [15, 38, 39, 49].
4 days ago · The network includes regions associated with empathy in humans (somatosensory cortex, insula, cingulate cortex and frontal cortex), and motivation and reward regions such as the nucleus accumbens. Oxytocin receptor mRNA expression levels were higher in the accumbens but not the anterior insula.
4 days ago · Dopamine Receptors. Five different dopamine receptors (D 1 –D 5) have been characterized. Each is G protein-coupled and contains 7 transmembrane domains. The D 2 receptor, found in the caudate putamen, nucleus accumbens, cerebral cortex, and hypothalamus, is negatively coupled to adenylyl cyclase.
1 day ago · Dopaminergic neurons in the nucleus accumbens (NAc) and the ventral tegmental area (VTA) play an important role in the perception of rewarding stimuli, such as the rewards related with substance addiction [13,17]. After cocaine treatments, the extracellular dopamine (DA) contents increased dramatically.
