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When rewarding stimuli are experienced, the dopaminergic mesolimbic system is activated which causes the release of dopamine to the targeted nuclei ( Small et al. 2003; Cameron et al. 2014 ). The ventral striatum, including the nucleus accumbens (NAcc), is a major substrate involved in reward ( Marche et al. 2017 ).
Oct 18, 2019 · The nucleus accumbens (NAc) is a subcortical brain structure known primarily for its roles in pleasure, reward, and addiction. Despite less focus on the NAc in pain research, it also plays a large role in the mediation of pain and is effective as a source of analgesia.
Abstract. There is increasing interest among functional neurosurgeons in the potential for novel therapies to impact upon diseases beyond movement disorders and pain. A target of increasing interest is the nucleus accumbens (NAc), which has long been studied as a key brain region mediating a variety of behaviors, including reward and satisfaction.
Feb 8, 2023 · Published: 08 February 2023. Deep brain stimulation of the nucleus accumbens in treatment-resistant alcohol use disorder: a double-blind randomized controlled multi-center trial. Patrick...
Jul 22, 2022 · Objective: The nucleus accumbens (NAcc) of the ventral striatum is critically involved in goal- and reward-based behavior. Structural and functional abnormalities of the NAcc or its associated neural systems are involved in neurological and psychiatric disorders.
Efferent projections of the nucleus accumbens include fibers to the hypothalamus, nuclei of the brainstem, and the globus pallidus ( Fig. 31.9B ). Nucleus accumbens fibers to the last target represent an important route through which the limbic system may access the motor system. View chapter Explore book.
Oct 18, 2021 · The nucleus accumbens (NAc) plays an important role in regulating multiple behaviors, and its dysfunction has been linked to many neural disorders. However, the molecular, cellular and anatomic...
