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May 12, 2016 · An Old Idea, Revived: Starve Cancer to Death. In the early 20th century, the German biochemist Otto Warburg believed that tumors could be treated by disrupting their source of energy. His idea was ...
Apr 14, 2011 · Otto Warburg was a pioneering biochemistry researcher who made substantial contributions to our early understanding of cancer metabolism. Warburg was awarded the Nobel Prize in Physiology or ...
- Willem H. Koppenol, Patricia L. Bounds, Chi V. Dang
- 2011
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May 21, 2021 · Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate even in the presence of oxygen.
Otto Heinrich Warburg. Otto Heinrich Warburg ( German pronunciation: [ˈɔto ˈvaːɐ̯bʊʁk] ⓘ, / ˈvɑːrbɜːrɡ /; 8 October 1883 – 1 August 1970), son of physicist Emil Warburg, was a German physiologist, medical doctor, and Nobel laureate. He served as an officer in the elite Uhlan (cavalry regiment) during the First World War, and ...
Hypothesis. The hypothesis was postulated by the Nobel laureate Otto Heinrich Warburg in 1924. [6] He hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy (as e.g., adenosine triphosphate / ATP) by non-oxidative breakdown of glucose (a process called glycolysis ).
Jan 13, 2021 · Nearly a century ago, Otto Warburg discovered that tumors consume tremendous amounts of glucose relative to most non-transformed tissues, and that the majority of glucose consumed by tumors is fermented to lactate, rather than oxidized in pathways that require respiration [1]. This phenotype is referred to as “aerobic glycolysis,” because ...
Nov 21, 2023 · In 1923, Otto Warburg published his landmark study , in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His work laid ...
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