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Jun 26, 2019 · 2. Pain Pathways and Mechanisms of Chronic Pain . Pain can be classified into three major types: Nociceptive, inflammatory, and neuropathic pain. Nociceptive pain is the response of sensory systems to actual or potentially harmful stimuli detected by nociceptors around the body.
The human pain pathway evolved from an afferent representation of the physiological condition of the body, present in all vertebrates, that provides spinal and brainstem regions involved in homeostatic integration and autonomic control with modality-selective input from small-diameter primary afferent fibers by way of lamina I neurons.
Jul 10, 2018 · The spinal dorsal horn can be divided into six parallel laminae based on neuronal size and packing density (Rexed, 1952), and this scheme has been used to define the regions targeted by different types of primary afferent (Figure 15.1), as well as to define specific populations of spinal cord neurons.
‘Pain Transduction’ by Casey Henley is licensed under a Creative Commons Attribution Non-Commercial Share-Alike (CC BY-NC-SA) 4.0 International License. Pathway to Brain Spinal Cord Branching. Primary afferent pain fibers have their cell bodies located in the dorsal root ganglion, like the fibers of the mechanoreceptors responsible for touch.
Pain signaling pathways involve many molecular components that could potentially be targets for pharmacotherapeutic intervention, but the complexity of this system might also mean that multiple ...
Pain signals can set off autonomic nervous system pathways as they pass through the medulla, causing increased heart rate and blood pressure, rapid breathing and sweating. The extent of these reactions depends upon the intensity of pain, and they can be depressed by brain centers in the cortex through various descending pathways.
Feb 11, 2019 · The goal of this article is to methodically but simply walk through the pain pathway as it is currently understood, and show where therapies, both pharmacologic and physical, can intervene. The 4 Steps of the Pain Pathway: Transduction, Transmission, Modulation, and Perception.
