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  1. 1-Phenylcyclohexylamine | C12H17N - PubChem

    pubchem.ncbi.nlm.nih.gov › 1-phenylcyclohexylamine

    1-Phenylcyclohexylamine is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.

  2. Synthesis and anticonvulsant activity of 1 ...

    pubmed.ncbi.nlm.nih.gov › 2329567

    Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites …

    • Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
    • 73
    • 1990
  3. Use of PCA (1-phenylcyclohexylamine) as a precursor

    erowid.org › archive › rhodium

    Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.

  4. Structure-guided design and synthesis of P1′ position 1 ...

    www.sciencedirect.com › science › article

    Sep 01, 2011 · Compound 7b was synthesized from 1-phenylcyclohexanol 6b in 69% of yield as colorless liquid by following the similar procedure used for synthesis of 7a.

    • Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Koushi Hidaka, Takashi Hamada, Youhei Sohma...
    • 17
    • 2011
  5. Arylcyclohexylamine - Wikipedia

    en.wikipedia.org › wiki › 1-phenylcyclohexylamine

    Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis, beginning with the 1956 synthesis of phencyclidine and later the related compound ketamine. The 1970s saw the debut of these compounds, especially PCP and its analogues, as illicitly used recreational drugs due to their dissociative hallucinogenic and euphoriant effects.

  6. Anticonvulsant activities of 1-phenylcyclohexylamine and its ...

    www.ncbi.nlm.nih.gov › pubmed › 2659775

    1-Phenylcyclohexylamine (PCA), an analog of phenyclidine (PCP) in which the piperidine ring is replaced by a primary amino group, and its conformationally restricted ...

    • Michael A Rogawski, A. Thurkauf, S. I. Yamaguchi, K. C. Rice, A. E. Jacobson, M. V. Mattson
    • 22
    • 1989
  7. US3145229A - Process for the production of nu-substituted-1 ...

    patents.google.com › patent › US3145229A

    phenylcyclohexylamine water salt Prior art date 1960-04-04 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Expired - Lifetime Application number US19477A Inventor Erik F Godefroi Robert F Parcell

  8. N-Ethyl-1-phenylcyclohexylamine (3) (Procedure B).--A solu- tion of 76 g (0.5 mole) of 25 in 200 ml of Et90 was added to PhLi [prepared from 236 g (1.5 moles) of PhBr and 25 g of I,i ribbon in 800 ml of Et201 at such a rate that a gentle reHux w-as maintained. The mixture was heated and stirred 30 min, then filtered quickly,

  9. May 01, 1990 · Synthesis, radiosynthesis, and biological evaluation of fluorinated thienylcyclohexyl piperidine derivatives as potential radiotracers for the NMDA receptor-linked calcium ionophore. Nuclear Medicine and Biology 1996, 23 (3) , 315-324.

    • Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
    • 73
    • 1990
  10. This article is cited by 2 publications. Wilder D. Bancroft. Over-Voltage and Monatomic Hydrogen. The Journal of Physical Chemistry 1916, 20 (5) , 396-401.

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