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The raphe nuclei (Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein -inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.
The dorsal raphe nucleus is one of the raphe nuclei. It is situated in the brainstem at the midline. It has rostral and caudal subdivisions: The rostral aspect of the dorsal raphe is further divided into interfascicular, ventral, ventrolateral and dorsal subnuclei.
May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.
- Emily P. Walker, Prasanna Tadi
- 2023/05/01
- 2019
The raphe nuclei are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein-inhibiting adenyl...
Aug 14, 2019 · The dorsal raphe nucleus (DRN) is a major source of neuromodulators in the central nervous system, and is the largest of the serotonergic nuclei, containing approximately a third of all serotonergic neurons (5-HT neurons) in the brain (Hornung, 2010).
- Kee Wui Huang, Nicole E Ochandarena, Adrienne C Philson, Minsuk Hyun, Jaclyn E Birnbaum, Marcelo Cic...
- 10.7554/eLife.46464
- 2019
- eLife. 2019; 8: e46464.
The raphe nucleus refers to a cluster of nuclei within the brainstem, and is the major source of serotoninergic neurons within the brain. These neurons have widespread projections to cortical and forebrain structures (Frazer and Hensler, 1998).
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The nucleus raphe magnus (NRM) is one of the seven raphe nuclei. It is situated in the pons in the brainstem, [1]: 306 just rostral to the nucleus raphe obscurus. [citation needed]
