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May 14, 2021 · Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology.
Mar 21, 2019 · Sepsis is a systemic response to infection, manifested by two or more of the SIRS criteria as a result of infection. Severe sepsis: Sepsis associated with organ dysfunction, hypoperfusion, or hypotension; hypoperfusion and perfusion abnormalities may include, but not limited to, lactic acidosis, oliguria, or an acute alteration in mental status
Feb 10, 2023 · Overview. Sepsis is a serious condition in which the body responds improperly to an infection. The infection-fighting processes turn on the body, causing the organs to work poorly. Sepsis may progress to septic shock. This is a dramatic drop in blood pressure that can damage the lungs, kidneys, liver and other organs.
Jan 18, 2024 · Sepsis results when the response to infection becomes generalized and involves normal tissues remote from the site of injury or infection. The pathophysiology of sepsis and mechanisms of multiple organ system dysfunction are reviewed here. The definition and management of sepsis are discussed separately.
May 23, 2016 · In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune dysfunction and catabolism. Much has been learnt about the pathogenesis of sepsis at the molecular, cell, and intact organ level.
Jan 19, 2023 · Overview. What is sepsis? Sepsis is a life-threatening medical emergency caused by your body’s overwhelming response to an infection. Without urgent treatment, it can lead to tissue damage, organ failure and death. Sepsis definition. Sepsis is your body’s extreme reaction to an infection.
Jul 7, 2021 · Sepsis can develop during the body’s response to a critical illness leading to multiple organ failure, irreversible shock, and death. Sepsis has been vexing health care providers for centuries due to its insidious onset, generalized metabolic dysfunction, and lack of specific therapy.
