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Mar 17, 2022 · Sodium nitrite toxicity is capable of causing severe methemoglobinemia with high mortality. Prompt identification is crucial. We discuss the important implications in regard to media coverage, imitative suicide, and accessibility of sodium nitrite.
Toxicity. Sodium nitrite is toxic. The LD 50 in rats is 180 mg/kg and in humans LD Lo is 71 mg/kg. The mechanism by which sodium nitrite causes death is methemoglobinemia. The oftentimes severe methemoglobinemia found in sodium nitrite poisoning cases results in systemic hypoxia, metabolic acidosis, and cyanosis.
Ingestion of nitrite (from potassium nitrite or sodium nitrite sources) has been associated with severe methemoglobinemia in adults and children; in some of these cases, symptoms included hypotension and/or tachycardia ( Gowans 1990; Sevier and Berbatis 1976; Ten Brink et al. 1982 ).
Misuse or excessive use of any medicine or product containing nitrates, whether unintentionally or intentionally, can lead to poisoning. Poisoning can result from swallowing, inhaling, or even skin contact. People have been poisoned after drinking nitrate-contaminated rural well water.
Sodium Nitrite. The incidence of intentional self-poisoning with sodium nitrite has been increasing since 2017. Many of these exposures result in toxicity requiring antidotal therapy, and a high mortality rate was observed. Recent literature indicates that this trend may be the result of ready access to this poison ….
Feb 1, 2024 · Documented cases of sodium nitrite toxicity are almost exclusively caused by accidental ingestion; however, self-poisoning with sodium nitrite represents an increasing trend in nitrate-related deaths. This systematic review summarizes the most crucial evidence regarding the fatal toxicity of sodium nitrite.
Nov 5, 2020 · Clinical manifestations can include cyanosis, hypoxia, altered consciousness, dysrhythmias, and death. The majority of reports on sodium nitrite poisonings have been the result of unintentional exposures. We report a case of an intentional fatal overdose of sodium nitrite.
