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  1. Oct 12, 2010 · The Spanish flu pandemic of 1918, the deadliest in history, infected an estimated 500 million people worldwide—about one-third of the planet’s population—and killed an estimated 20 million ...

  2. Red Cross workers make anti-influenza masks for soldiers, Boston, Massachusetts. (National Archives Identifier 45499341) Before COVID-19, the most severe pandemic in recent history was the 1918 influenza virus, often called “the Spanish Flu.”. The virus infected roughly 500 million people—one-third of the world’s population—and caused ...

  3. Mar 29, 2019 · The influenza pandemic of 1918 killed more than 50 million people worldwide. In addition, its socioeconomic consequences were huge. “Spanish flu”, as the infection was dubbed, hit different age-groups, displaying a so-called “W-trend”, typically with two spikes in children and the elderly. However, healthy young adults were also affected.

    • Mariano Martini, Valentina Gazzaniga, Nicola Luigi Bragazzi, Ilaria Barberis
    • 2019
  4. Apr 15, 2024 · Influenza is caused by a virus that is transmitted from person to person through airborne respiratory secretions. An outbreak can occur if a new strain of influenza virus emerges against which the population has no immunity. The influenza pandemic of 1918–19 resulted from such an occurrence and affected populations throughout the world.

    • The Editors of Encyclopaedia Britannica
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  5. The 1918Spanish flupandemic was caused by a founder H1N1 influenza A virus. The three subsequent pandemics of 1957, 1968, and 2009 (black arrows) were caused by descendants of the 1918 virus, which acquired one or more genes through reassortment . Colored horizontal lines reflect the years of annual epidemics of seasonal influenza that ...

    • Jeffery K. Taubenberger, John C. Kash, David M. Morens
    • 2019
  6. en.wikipedia.org › wiki › Spanish_fluSpanish flu - Wikipedia

    The 1918–1920 flu pandemic, also known as the Great Influenza epidemic or by the common misnomer Spanish flu, was an exceptionally deadly global influenza pandemic caused by the H1N1 influenza A virus. The earliest documented case was March 1918 in the state of Kansas in the United States, with further cases recorded in France, Germany and ...

  7. Abstract. The "Spanish" influenza pandemic of 1918–1919, which caused ≈50 million deaths worldwide, remains an ominous warning to public health. Many questions about its origins, its unusual epidemiologic features, and the basis of its pathogenicity remain unanswered. The public health implications of the pandemic therefore remain in doubt ...

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