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  1. Stiff-person syndrome (SPS), also known as stiff-man syndrome, is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms , resulting in postural deformities.

  2. Stiff Person Syndrome (SPS) is an autoimmune and neurological disorder that can make the muscles in the torso and limbs alternate between rigidity and spasms. The cause of this extremely rare disease is still unknown.

  3. Jul 11, 2023 · Stiff person syndrome (SPS) is a rare acquired neurological disorder that most often causes progressive muscle stiffness (rigidity) and repeated episodes of painful muscle spasms. Muscular rigidity often fluctuates (i.e., grows worse and then improves) and usually occurs along with the muscle spasms.

  4. Stiff-person syndrome causes muscle stiffness that worsens gradually. Stiff-person syndrome often occurs in people with type 1 diabetes, certain autoimmune disorders, or certain kinds of cancer. Muscles gradually become stiffer and enlarge, starting in the trunk and abdomen but eventually affecting muscles throughout the body.

  5. Dec 8, 2022 · Deb Balzer. December 8, 2022. Stiff-person syndrome is an autoimmune disorder of the nervous system, often resulting in progressive, severe muscle stiffness and spasms of the lower extremities and back. It also can affect other body regions.

  6. Stiff person syndrome is a rare disease affecting only one or two people per million. It commonly causes muscle stiffness and painful spasms that worsen over time. They can be triggered by a variety of things including sudden movement, cold temperature or unexpected loud noises. Learn more about stiff person syndrome. Watch on.

  7. Key Points. Stiff-person syndrome is a CNS disorder that causes progressive muscle stiffness and spasms. (See also Overview of Peripheral Nervous System Disorders.) Stiff-person syndrome (formerly called stiff-man syndrome) affects the central nervous system (CNS) but has neuromuscular manifestations.

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