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  1. 2 days ago · Von Willebrand Disease (VWD) is a genetic bleeding disorder that affects the blood's ability to clot properly. It is named after Erik von Willebrand, a Finnish physician who first described the condition in the 1920s. VWD is caused by a deficiency or dysfunction of Von Willebrand factor (VWF), a protein that plays a crucial role in the clotting ...

  2. 5 days ago · Von Willebrand disease (VWD) is the most common congenital bleeding disorder in the world and could affect more than 3 million people in the U.S. Up to 90% of people with VWD are misdiagnosed or undiagnosed. Many people, including some medical providers, simply cannot identify abnormal bleeding.

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  4. 4 days ago · activated clotting factors: high levels for factors VII, VIII, X, von Willebrand factor, and fibrinogen. decreased anticoagulant factors: protein S level , adapted resistance to activated protein C. inhibiting fibrinolytic factors: increased activatable fibrinolytic inhibitor (TAFI), plasminogen activator inhibitor 1 and 2 (PAI-1 and PAI-2).

  5. 4 days ago · Again, this has to do with hormones. Being sick puts stress on your body, which can disrupt your delicate hormonal balance. This is also why illness can delay your period, or cause irregular ...

  6. 5 days ago · Clot-Stabilizing Medication. Clot-stabilizing medication is one of the standard treatments doctors provide for most patients with von Willebrand disease. Known as anti-fibrinolytic medicines ...

  7. 5 days ago · The patient’s mean ratio of von Willebrand factor activity to antigen was 0.86±0.19 while she was receiving rADAMTS13 and rose to 1.02±0.04 after discontinuing therapy (Fig. S4).

  8. 2 days ago · Additionally, hyperthyroidism has been implicated as a procoagulant state through multiple mechanisms, including elevated Factor VIII, Factor IX, von Willebrand factor, and fibrinogen levels and lower plasma levels of plasminogen and tissue plasminogen activator and endothelial dysfunction leading to reduced fibrinolytic activity. 2 Few studies ...

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