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The first person who was treated with streptomycin did not survive; the second person survived but became blind as a side effect of the treatment. In March 1946, the third person—Robert J. Dole, later Majority Leader of the United States Senate and presidential nominee—experienced a rapid and robust recovery.
- 84% to 88% IM (est.) 0% by mouth
- Kidney
- C₂₁H₃₉N₇O₁₂
The death rates associated with the disease also dropped off precipitously: while in 1930, 70 out of every 100,000 people in the United States died from the disease, by 1954 only 10 out of every 100,000 did. The advent of a cure greatly reduced the fears surrounding the disease and virtually ended the Sanatorium movement.
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Jul 4, 2023 · Streptomycin is the first discovered aminoglycoside antibiotic, originally isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis. It has additional activity against several aerobic gram-negative bacteria. This activity will discuss the indications, mechanism of action, and contraindications of using streptomycin ...
- Mitchell Waters, Prasanna Tadi
- 2023/07/04
Jul 5, 2017 · The first antibiotic to be discovered from nature was ... of antibiotics was the discovery of streptomycin ... were prescribed antibiotics between 2007 and 2009 in the United States, ...
- Kyriacos C Nicolaou, Stephan Rigol
- 2018
Sep 12, 2022 · Extending the linear part of the sigmoidal discovery curve in Figure 1 allows us to better define the Golden Age as 1943–1962, when streptomycin and the quinolones were discovered, respectively. A 2011 review in Clinical Microbiology Reviews defined the “discovery void”, during which no new antibiotic classes have been discovered, as ...
- 10.3390/antibiotics11091237
- 2022/09
- Antibiotics (Basel). 2022 Sep; 11(9): 1237.
Jul 21, 2020 · Co-cultivation. It is quite typical to find multiple species of Streptomyces in traditional medical preparations such as soil or moonmilk [ 50, 54, 64 ]. Now, it has been discovered that competition and collaboration between Streptomyces and other species can also awaken silent antibiotic-synthesis clusters [ 65 ].
streptomycin, antibiotic synthesized by the soil organism Streptomyces griseus. Streptomycin was discovered by American biochemists Selman Waksman, Albert Schatz, and Elizabeth Bugie in 1943. The drug acts by interfering with the ability of a microorganism to synthesize certain vital proteins. It was the first antimicrobial agent developed ...
