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  1. Methods: SLE patients of European descent (n=1,754) from 8 case collections were genotyped for >1,400 ancestry informative markers that define a north-south gradient of European substructure. Using the Structure program, each SLE patient was characterized in terms of percent Northern (versus percent Southern) European ancestry based on these genetic markers.

  2. European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal ...

    • Chao Tian, Robert M Plenge, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Se...
    • 2008
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  4. For the European substructure analysis, the same parameters were utilized in STRUCTURE runs with the exception that the number of replicates and burn-in cycles were reduced to 50,000 each. Runs were performed including 150 southern and 150 northern European subjects determined from previous studies . Four independent runs demonstrated nearly identical results under these parameters.

    • Sharon A. Chung, Chao Tian, Kimberly E. Taylor, Annette T. Lee, Ward A. Ortmann, Geoffrey Hom, Rober...
    • 2009
  5. Previous work has demonstrated that Northern and Southern European ancestries are associated with specific systemic lupus erythematosus (SLE) manifestations. In this study, 1855 SLE cases of European descent were genotyped for 4965 single-nucleotide polymorphisms and principal components analysis of …

  6. Download scientific diagram | Analysis of European Substructure in Northern European Individuals (A) The first two PCs are depicted for RA cases and NYCP controls. (B) Color codes show the Irish ...

  7. May 24, 2022 · per stirpes is a legal term stipulating that should a beneficiary predecease the testator—the person who has made the will—the beneficiary's share of the inheritance goes to that beneficiary's...

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