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Jan 18, 2008 · Abstract. European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry.
- Chao Tian, Robert M Plenge, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Se...
- 10.1371/journal.pgen.0040004
- 2008
- PLoS Genet. 2008 Jan; 4(1): e4.
Jan 18, 2008 · Author SummaryAncestry differences corresponding to ethnic groups may be important in determining disease risk factors and optimizing treatment. Our study further defines ancestry relationship among different European ethnic groups by examining over 300 thousand variations in DNA, in over 2,000 individuals. This study allowed a clearer ascertainment of differences that could not be discerned ...
- Chao Tian, Robert M Plenge, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Se...
- 2008
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What is a European population substructure?
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Which populations are included in European substructure studies?
Differences between European Populations A set of 952 self-identified participants of diverse European descent genotyped with .300K SNPs was used for the first phase of European population substructure analysis. This participant group predominantly included European Amer-icans as well as smaller numbers of individuals from Italy and
Aug 24, 2009 · The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4000 subjects genotyped for 300 thousand SNPs we provide further insight ...
- Population Differentiation Among European Populations
- Principal Components Analyses Using >250,000 SNPs
- PCA of Northern and Southern European Population Groups
- PCA of European and South Asian Population Groups
- Identification and Testing of European Substructure Ancestry Informative Markers
- Performance of Esaims in Controlling For Population Substructure
To examine similarities and differences in population differentiation among European and closely related populations, paired Fst values were determined between 18 population groups that were typed with genome-wide SNP arrays (see Materials and Methods). The studies included genotypes derived from HGDP (14), and samples collected in Europe and Europ...
To further explore the relationship among European population groups and examine population substructure, PCA was performed using the genotype results from a set of ~300,000 autosomal SNPs that was common to each of the populations examined. For most individuals with self-reported ethnic identities there was a general correspondence with the geogra...
Our previous studies showed that further elucidation of the relationships among Northern European individuals was possible when analyses were performed excluding subjects of southern European origin. For the current study, we next examined Northern and Southern population groups separately and the effect of including or excluding different ethnic g...
To further explore the relationship of population groups in Europe, we also performed PCA including the HGDP South Asian groups, Burusho, and Balochi. These South Asian population groups showed relatively small population differentiation with continental European subjects (14,17,26,27). Thus inclusion of these populations might further suggest clin...
AIMs that discern population substructure are likely to be useful in candidate gene, chromosomal position-based association studies, and defining homogeneous subject sets (28). Our previous studies identified two sets of European substructure AIMs (ESAIMs): ns-ESAIMs and north-ESAIMs. The ns-ESAIMs separated European populations on a single axis (n...
To further assess the potential value and performance of ESAIMs we examined SNPs with large (10% to 25%) allele frequency differences between different European subgroups. The different subgroups were selected based on PCA results and included both individuals with self-identified ethnic affiliation and those without known self-identity information...
- Chao Tian, Roman Kosoy, Rami Nassir, Annette Lee, Pablo Villoslada, Lars Klareskog, Lennart Hammarst...
- 2009
Sep 15, 2006 · Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there is a consistent and reproducible distinction between “northern” and “southern” European population groups: most individual participants with southern European ancestry (Italian, Spanish ...
May 8, 2009 · Figure 2. The European genetic structure (based on 273,464 SNPs). Three levels of structure as revealed by PC analysis are shown: A) intercontinental; B) intra-continental; and C) inside a single country (Estonia), where median values of the PC1&2 are shown. D) European map illustrating the origin of sample and population size. CEU - Utah residents with ancestry from Northern and Western ...
