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Jan 18, 2008 · European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry.
- Chao Tian, Robert M Plenge, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Se...
- 2008
Jan 1, 2008 · A set of 952 self-identified participants of diverse European descent genotyped with >300K SNPs was used for the first phase of European population substructure analysis. This participant group predominantly included European Americans as well as smaller numbers of individuals from Italy and Spain (see Methods ).
- Chao Tian, Robert M Plenge, Robert M Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Se...
- 2008
Jul 4, 2008 · Here, we study the genetic sub-structure of the European American population, analyzing 1,521 individuals for over 300,000 SNPs across the entire genome. Applying a powerful method that is based on dimensionality reduction (Principal Components Analysis), we are able to identify 200 SNPs that successfully represent the complete dataset.
- Peristera Paschou, Petros Drineas, Jamey Lewis, Caroline M. Nievergelt, Caroline M. Nievergelt, Debo...
- 2008
Molecular data. We used Qiagen DNeasy kits (Qiagen, Hilden, Germany) to extract and purify genomic DNA from each sample following the manufacturer's protocol for animal tissues. In the case of feathers, 20 μL of dithiothreitol (DTT) 1 M was added to the digestion buffer to achieve complete digestion.
May 8, 2009 · Two sets of European substructure ancestry informative markers (ESAIMs) were identified that provide substantial substructure information that can be used for improving error rates in association testing of candidate genes and in replication studies of WGA scans. Expand
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Jul 27, 2017 · Introduction. Ancient genomics, through direct sampling of the past, has allowed an unprecedented parsing of the threads of European ancestry. Most strikingly, longitudinal studies of genomewide variation have revealed that two major technological innovations in prehistory, agriculture and metallurgy, were associated with profound population change [1–5].
