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  1. Nov 24, 2020 · Pathogenesis of Dengue. The four dengue virus serotypes (DENV1–4) have a 65–70% nucleotide sequence homology and are closely related [].Primary infection is defined as the initial or first infection with a certain serotype.

  2. Aug 14, 2023 · Substantial gaps remain in the comprehensive understanding of the pathogenesis of dengue virus (DENV) infections. In large part, this limitation is related to the lack of a suitable animal model of disease [ 1 ]. Rhesus monkeys develop RNAemia and viremia similar in a pattern to humans after DENV challenge but do not develop clinical disease.

  3. Apr 23, 2024 · Dengue is a viral infection transmitted to humans through the bite of infected mosquitoes. About half of the world's population is now at risk of dengue with an estimated 100–400 million infections occurring each year. Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas.

  4. Apr 12, 2012 · Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding global footprint of dengue is a public health challenge with an economic burden ...

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