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- This review aims to summarize the complex interaction between DENV and the host cellular machinery, comprising regulatory mechanisms at various molecular levels such as epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-translational regulation of viral proteins, and pathways involved in protein degradation.
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Oct 2, 2023 · Most people with dengue have mild or no symptoms and will get better in 1–2 weeks. Rarely, dengue can be severe and lead to death. If symptoms occur, they usually begin 4–10 days after infection and last for 2–7 days. Symptoms may include: high fever (40°C/104°F) severe headache. pain behind the eyes.
Apr 24, 2024 · The objective of this study was to explore whether the specific serotypes and antigenic distance between viruses causing primary and secondary infections are linked to dengue disease risk after a secondary infection.
Apr 25, 2024 · Abstract. Dengue virus (DENV) is a medically important flavivirus causing an estimated 50–100 million dengue cases annually, some of whom progress to severe disease. DENV non-structural protein 1 (NS1) is secreted from infected cells and has been implicated as a major driver of dengue pathogenesis by inducing endothelial barrier dysfunction.
Apr 15, 2024 · A complex interaction among virulence factors, host-genes and host immune system is considered to be responsible for dengue virus (DENV) infection and disease progression. Generation of auto-antibodies during DENV infection is a major phenomenon that plays a role in the pathophysiology of dengue hemorrhagic fever and dengue shock syndrome.
May 4, 2024 · Introduction. Dengue is the most prevalent arboviral infection in the world [ 1, 2, 3, 4 ]. There are currently four globally circulating serotypes of dengue virus, the causative agent (DENV1-4), that are related but serologically distinct [ 1, 5 ].
Apr 25, 2024 · Dengue is an acute febrile illness viral infection caused by dengue virus (DENV), which is transmitted to humans through the bite of an infected Aedes mosquito 1,2,3.There are four genetically ...
