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Cells within the nucleus accumbens have receptors for a variety of neurotransmitters, including endogenous opiates. The nucleus accumbens may play an important role in behaviors related to addiction and chronic pain. Recent observations in addicted humans likewise reinforce the concept that the nucleus accumbens is a gratification site.
Here, we review the existing literature regarding several areas critical to the development of new therapies, including the known pharmacology, physiology, and connectivity of the NAc, as well as evidence supporting the potential for various NAc surgical therapies in animal models.
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The nucleus accumbens (NAc) is a key node of the brain’s circuitry that is responsible for translating motivation into action. It has been implicated in playing critical roles in virtually all forms of adaptive and pathological motivated behaviors.
Jan 1, 2022 · Nucleus accumbens (NAc) is a brain area found in basal forebrain. It is present in between caudate and putamen nuclei of basal ganglia. NAc is also the main component of ventral striatum. Most importantly NAc is implicated in reward pathway of brain.
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action. Stan B. Floresco 1. View Affiliations. Vol. 66:25-52 (Volume publication date January 2015) https://doi.org/10.1146/annurev-psych-010213-115159. First published as a Review in Advance on September 17, 2014. © Annual Reviews. info Info. list Sections. PDF. build Tools.
The nucleus accumbens (NAc) is a central component of the mesocorticolimbic reward system. Increasing evidence strongly implicates long-term synaptic neuroadaptations in glutamatergic excitatory activity of the NAc shell and/or core medium spiny neurons in response to chronic drug and alcohol exposure.
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Oct 18, 2019 · The nucleus accumbens (NAc) is a subcortical brain structure known primarily for its roles in pleasure, reward, and addiction. Despite less focus on the NAc in pain research, it also plays a large role in the mediation of pain and is effective as a source of analgesia.
