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  1. Synthesis and anticonvulsant activity of 1 ...

    pubmed.ncbi.nlm.nih.gov › 2329567

    Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites …

    • Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
    • 71
    • 1990
  2. Use of PCA (1-phenylcyclohexylamine) as a precursor

    erowid.org › archive › rhodium

    Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.

  3. Synthesis and anticonvulsant activity of 1 ...

    ucdavis.pure.elsevier.com › en › publications

    title = "Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues", abstract = "Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding ...

    • Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
    • of Medicinal Chemistry
    • 1990
    • English (US)
  4. Structure-guided design and synthesis of P1′ position 1 ...

    www.sciencedirect.com › science › article

    Sep 01, 2011 · 1-Phenylcyclohexylamine (8b) Compound 8b was synthesized from 1-(1-azidocyclohexyl)benzene 7b by similar procedure used for synthesis of compound 8a. Yield: (98.5 mg, 67%); TLC: R f = 0.21 (hexane/EtOAc = 1:1); ESI-MS m/z 198.1 for [M+Na] +. 5.3. Synthesis of 1-benzyl-4-phenylpiperidin-4-amine (12) 5.3.1. 1-Benzylpiperidin-4-one (9)

    • Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Koushi Hidaka, Takashi Hamada, Youhei Sohma...
    • 17
    • 2011
  5. Phenylcyclohexylamine: Effect of a metabolite of ...

    www.sciencedirect.com › science › article

    Dec 01, 1986 · Phenylcyclohexylamine produced a long-lasting dose-dependent biphasic effect on the efflux of DA in the rat. This response, to one of the major metabolites of phencyclidine, was similar in duration to but less potent than that seen with phencyclidine. Key words: phencyclidine, phenylcyclohexylamine, dopamine, in vivo voltammetry, neostriatum.

    • H. Takeda, R.A. Gazzara, S.G. Howard
    • 13
    • 1986
  6. US3145229A - Process for the production of nu-substituted-1 ...

    patents.google.com › patent › US3145229A

    phenylcyclohexylamine water salt Prior art date 1960-04-04 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Expired - Lifetime Application number US19477A Inventor Erik F Godefroi Robert F Parcell

  7. Arylcyclohexylamine - Wikipedia

    en.wikipedia.org › wiki › 1-phenylcyclohexylamine

    Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis, beginning with the 1956 synthesis of phencyclidine and later the related compound ketamine. The 1970s saw the debut of these compounds, especially PCP and its analogues , as illicitly used recreational drugs due to their dissociative hallucinogenic and euphoriant effects.

  8. Characterization of N Ethyl 1 Phenylcyclohexylamine Reaction ...

    www.astm.org › DIGITAL_LIBRARY › JOURNALS

    Impurities found in the two principal methods of the manufacture of N -ethyl-1-phenylcyclohexylamine (cyclohexamine, PCE) are identified. Identification of N -ethylcyclohexanecarbonitrile allows the forensic science analyst to determine the specific synthesis route.

    • Robert H. Krefft, Scott S. Masumoto, Terry V. Caldwell
    • 1989
  9. Reaction Scheme III. Synthesis via imines: - Erowid

    erowid.org › archive › rhodium

    Synthesis via imines: This is the best route for synthesis of compounds with mono N-alkyl substituents, such as PCE (ref. 10). An intermediate imine is formed by the reaction of cyclohexanone and the appropriate primary amine. The phenyl group can then be introduced with phenyllithium (ref 15, 16).

  10. May 01, 1990 · Synthesis, radiosynthesis, and biological evaluation of fluorinated thienylcyclohexyl piperidine derivatives as potential radiotracers for the NMDA receptor-linked calcium ionophore. Nuclear Medicine and Biology 1996, 23 (3) , 315-324.

    • Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
    • 71
    • 1990
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