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      • An attractive procedure from the standpoint of clandestine synthesis would be the reductive alkylation of PCA with acetone and aluminum amalgam to give the potent analog N-isopropyl phenylcyclohexylamine. The first method using PCA as an intermediate is Scheme IV.
      chemistry.mdma.ch/hiveboard/rhodium/pcp/pca_synth.html
  1. Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues. Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites ….

    • Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
    • 1990
  2. Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.

  3. Dec 01, 1986 · The effect of phenylcyclohexylamine (PCA) on the efflux of dopamine (DA) in the neostriatum was examined using in vivo electrochemical techniques. Phe…

    • H. Takeda, R.A. Gazzara, S.G. Howard
    • 1986
  4. Anti-Inflammatory Agents / chemical synthesis* Anti-Inflammatory Agents / pharmacology Chromatography, Gas

  5. Arylcyclohexylamine anesthetics were intensively investigated at Parke-Davis, beginning with the 1956 synthesis of phencyclidine and later the related compound ketamine. The 1970s saw the debut of these compounds, especially PCP and its analogues , as illicitly used recreational drugs due to their dissociative hallucinogenic and euphoriant effects.

    Compound
    Aryl Substituent
    N Group
    Cyclohexyl Ring
    2-HO-PCP
    Phenyl
    Piperidine
    2-Hydroxy
    2-Me-PCP
    Phenyl
    Piperidine
    2-Methyl
    2-MeO-PCP
    Phenyl
    Piperidine
    2-Methoxy
    2-Keto-PCP
    Phenyl
    Piperidine
    2-Keto
  6. 1-( I-Pheiiylcyclohesyl)piperidine, the first compouiid of this type synthesized, was prepared from I-piperidinocyclohexanecarbonitrile by replacement of the cyano group by phenyl using phenylmagnesirim bromide. These compoimds were kited for cataleptoid itctivity and antitonic extensor properties.

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