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  1. Dec 17, 2022 · Minipress (prazosin), a drug commonly used to treat high blood pressure and urinary retention, has been shown in some studies to be safe and effective in managing nightmares and sleep disturbances in people with post-traumatic stress disorder (PTSD).

  2. Prazosin is a well-tolerated generically available medication that has a small but positive evidence base for the treatment of PTSD-associated nightmares. Given the difficulty of treating nightmares, combined with the continued presence of patients with nightmares, prazosin can be an important pharmacologic treatment option.

  3. Sep 7, 2022 · Prazosin. How it works. Side effects. Warnings. PTSD medications. Other treatments. Management. Summary. One possible medical treatment for post-traumatic stress disorder (PTSD) nightmares is...

  4. Oct 18, 2023 · Prazosin — Prazosin, an alpha-1 adrenergic receptor antagonist, is the best studied medication for nightmares and has been the preferred first-line pharmacotherapy when medication is deemed necessary . Trials of prazosin in patients with PTSD published subsequent to the AASM literature review have had conflicting results, however .

  5. Oct 8, 2010 · Prazosin demonstrated favorable clinical efficacy and was found to be safe for relieving PTSD-associated nightmares. Conclusions: Current data indicate that prazosin is an effective agent for the treatment of nightmares associated with PTSD.

  6. Aug 17, 2023 · Prazosin has therapeutic use for benign prostatic hypertrophy (BPH), post-traumatic stress disorder (PTSD) associated nightmares, Raynaud phenomenon, pheochromocytoma, and scorpion envenomation. Prazosin was the first alpha antagonist used for BPH.

  7. Treatment of Nightmares With Prazosin: A Systematic Review. Simon Kung, MD; Zelde Espinel, MD, MPH; and Maria I. Lapid, MD. Abstract. Nightmares, frequently associated with posttraumatic stress disorder and clinically relevant in today’s world of vio-lence, are difficult to treat, with few pharmacologic options.

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